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MIYATA LABORATORY For Material-driven Nanomedical Innovation

Miyata laboratory, Department of Materials Engineering, The University of Tokyo

Bld.#4, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656

東京大学 宮田研究室 Miyata Lab

Is it possible to make anticancer drugs with no adverse side effects?

Does the gene therapy come true?

What is the cell therapy? What does it do?

To make the answer to these questions, this laboratory creates new nanomedical devices based on materials engineering. Particularly, we have developed polymeric nanomaterials for drug and nucleic acid delivery. To realize the nucleic acid therapy, nucleic acids need to be delivered to the cytoplasm of target cells by overcoming various biological barriers. Smart materials that can exert the desired function in response to the biological microenvironment enable the creation of nanodevices for successful nucleic acid delivery. The fun of this "NanoBio" research is that the outcome can be dramatically improved by a slight change in material design. Meanwhile, there are many issues in this research field to overcome for ideal cancer therapy and cell therapy. Let's enjoy the NanoBio research with us!

 

What's new

2024
  • (Oct/1) One doctoral student and two master's students have joined our laboratory.
  • (July/11) At the 40th Annual Meeting of the Japan Society of Drug Delivery System, Dr. Jerry and D2 Chang have received the Science and Technology of Advanced Materials Award and the Materials Advances Award, respectively.
  • (July/8) Our original paper regarding the polymeric nanoruler targeting brain tumor has been highlighted in EurekAlert!.
    ≫ What is the optimal size that is more likely to accumulate in brain tumors selectively?
  • (July/2) Our original paper regarding “Polymeric nanoruler to optimize the nanomedicine size for the brain tumor targeting” has been accepted by Bioconjugate Chemistry.
  • (June/30) An academic specialist, Satomi OGURA, has retired.
  • (May/1) Dr. Naoki YAMADA has joined as a postdoctoral researcher.
  • (Feb/1) Dr. Mao HORI has moved to Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University as an assistant professor.
  • (Jan/31) Our original paper regarding “Effect of polypeptide hydrophobicity on antisense oligonucleotide delivery” has been published by Bioconjugate Chemistry.
  • (Jan/16) Our review paper regarding “Endosomal escape of polyplexes” has been published by Macromolecular Bioscience.
    ≫ Macromolecular Bioscience
2023
  • (Dec/5) Our original paper regarding “Development of a biocompatible polymer alternative to PEG” has been accepted by Journal of Applied Polymer Science.
  • (Sep/1) Assistant Professor Mitsuru Naito has been promoted to Lecturer.
  • (Jun/24) Our review paper regarding "Polymer-based RNA delivery” has been published by Advanced Drug Delivery Reviews.
    ≫ Advanced Drug Delivery Reviews
  • (May/1) Dr. Jongmin YUM has moved to Department of Neurology and Neurological Science, Tokyo Medical & Dental University.
2022
  • (Dec/1) Prof. Kanjiro Miyata has become a cooperating faculty member of Department of Bioengineering.
  • (Nov/19) Mr. Kohki Yamada (B4) has received Excellent Poster Award in 2022 International Graduate Symposium of Biopharmaceuticals. The presentation title is “Development of polymeric nanoparticles with precisely controlled PEG density for systemic mRNA delivery to the spleen”.
  • (Nov/1) Our original paper regarding “Design of nanomaterials for X-ray-mediated photodynamic therapy” has been published by ACS Applied Bio Materials.
    ≫ ACS Applied Bio Materals
  • (Oct/1) Dr Mao HORI has joined as a postdoctoral researcher, and Ms. Heemin CHANG and Ms. Nan QIAO have joined as doctor course students.
  • (May/31) Our research paper regarding muscle-targeted drug delivery has been highlighted on EurekAlert!.
    ≫ EurekAlert!
  • (May/20) Ms. Heemin CHANG has joined our laboratory as a research student.
  • (May/20) Our original paper regarding “Muscle accumulation of size-tunable polymeric nanomaterials (termed nanoruler)” has been accepted by Journal of Controlled Release.
  • (Apr/6) Dr Chun Yin (Jerry) LAU has joined our laboratory as a JSPS postdoctoral fellow.
  • (Apr/4) New undergraduates and graduate have joined our laboratory.
  • (Apr/1) Dr. Mitsuru Naito has arrived as an assistant professor in Department of Materials Engineering.
  • (Mar/24) Mr. Jongmin Yum and Rimpei Kamegawa has completed their PhD study and obtained PhD (Engineering).
  • (Mar/24) Mr. Rimpei Kamegawa (D3) has been commended as the chief graduate of the doctoral course in the Department of Materials Engineering.
  • (Jan/1) Associate Professor Kanjiro Miyata has been promoted to Professor.
2021
  • (Dec/31) Our original paper regarding “Systemic mRNA delivery by cationic/hydrophobic polyaspartamide derivatives” has been accepted by Journal of Controlled Release.
  • (Dec/6) Our original paper regarding “Effect of cationic chain length of Y-shaped block copolymers on the properties of siRNA-loaded unit polyion complexes” has been accepted by Biomacromolecules.
  • (Nov/30) Mr. Jongmin Yum (D3) has received Excellent Poster Presentation at The 43rd Annual Meeting of the Japanese Society for Biomaterials & The 8th Asian Biomaterials Congress. The presentation title is Development of amphiphilic polyaspartamide derivatives for systemic messenger RNA delivery.
  • (Oct/11) Our original paper regarding “Silica-coated polyion complexes for macrophage-targeted mRNA delivery” has been published by ACS Applied Bio Materials.
    ≫ Bioinspired Silicification of mRNA-Loaded Polyion Complexes for Macrophage-Targeted mRNA Delivery
  • (Oct/01) JSPS Postdoctoral Fellow Dr Debabrata Maiti has moved to Jikei University School of Medicine as a postdoctoral researcher.
  • (Sep/24) Mr. Hiroyuki Chaya has completed his PhD study and obtained PhD (Engineering).
  • (Apr/12) New undergraduate students have joined our laboratory.
  • (Jan/03) Our original paper regarding "Unit polyion complexes loaded with chemically modified oligonucleotide drugs" has been accepted by Journal of Controlled Release.
2020
2019
2018
2017
  • (Dec/31) Dr Yu Yi moved to The National Center for Nanoscience and Technology (China) as a research associate.
  • (Sep/01) Mr. HOGREL (M1) has joined our lab.
  • (Aug/25) Ms. Katano has resigned from our lab.
  • (Jul/07) A book written by Dr. Mitsuru Naito and associate professor Kanjiro Miyata as shared authors has been published from Technical Infromation Institute Co.;Ltd(ISBN978-4-86104-663-6).
    The title is "Application development of DDS advanced technology to formulation".
  • (Jul/01) Dr Kim Beob Soo has joined our lab as a project postdoctoral researcher.
  • (Jun/02) Associate Professor Kanjiro Miyata has received The Nucleic Acids Therapeutics Society of Japan (NatsJ) Award for Young Scientists.
  • (Apr/11) New undergraduate students have joined our Lab.
  • (Apr/01) Ms. Satomi OGURA has joined our Lab as a project academic support specialist.
  • (Mar/01) Our original paper regarding the silica-coated nanoparticles for cancer-targeted siRNA delivery has been accepted by Journal of Biomaterials Science, Polymer Edition.
    > Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery
  • (Jan/04) iCONM will hold the 11th Annual Symposium on Nanobiotechnology
    Date: Feb. 27 (Mon.) & 28 (Tue.) 9:30am -(Registration starts at 8:30am)
    Venue: Ground Floor & 4th Floor, Public Interest Incorporated Foundation, Kawasaki Institute of Industrial Promotion, Kawasaki City Industrial Promotion Hall
    Language: English (No simultaneous interpretation)
    Registration Fee: 3,000yen ※ Please register online.
    The symposium website can be found here.
2016
  • (Dec/08) Our collaboration study "Glioma-targeted antisense oligonucleotide delivery" with Department of Epigenomics, Nagoya City University Graduate School of Medicine, has been published in Nature Communications.
    > Targeting the notch-regulated non-coding RNA TUG1 for glioma treatment
    > Japan Agency for Medical Research and Development (AMED) Press Release (Japanese)
    > Nagoya City University Press Release (Japanese)
  • (Nov/01) Dr Yi Yu has joined our lab as a project postdoctoral researcher.
  • (Oct/25) Our review paper regarding polymeric nanocarriers for small nucleic acid delivery has been accepted by Drug Discoveries & Therapeutics.
  • (Sep/01) Dr Hyun Su MIN has received the JSPS Postdoctoral Fellowship for Overseas Researchers.
  • (Aug/29) Our original paper regarding the targeted siRNA nanocarrier fabricated from cRGD-installed unimer polyion complexes and gold nanoparticle has been accepted by Journal of Controlled Release.
  • (Jun/29) Our review paper regarding siRNA delivery has been accepted by Advanced Drug Delivery Reviews.
  • (Apr/11) New undergraduate students have joined our laboratory.
  • (Feb/03) We started a laboratory homepage.
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