Is it possible to make anticancer drugs with no adverse side effects?
Does the gene therapy come true?
What is the cell therapy? What does it do?
To make the answer to these questions, this laboratory creates new nanomedical devices based on materials engineering. Particularly, we have developed polymeric nanomaterials for drug and nucleic acid delivery. To realize the nucleic acid therapy, nucleic acids need to be delivered to the cytoplasm of target cells by overcoming various biological barriers. Smart materials that can exert the desired function in response to the biological microenvironment enable the creation of nanodevices for successful nucleic acid delivery. The fun of this "NanoBio" research is that the outcome can be dramatically improved by a slight change in material design. Meanwhile, there are many issues in this research field to overcome for ideal cancer therapy and cell therapy. Let's enjoy the NanoBio research with us!
What's new
- 2024
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- (July/8) Our original paper regarding the polymeric nanoruler targeting brain tumor has been highlighted in EurekAlert!.
≫ What is the optimal size that is more likely to accumulate in brain tumors selectively? - (July/2) Our original paper regarding “Polymeric nanoruler to optimize the nanomedicine size for the brain tumor targeting” has been accepted by Bioconjugate Chemistry.
- (June/30) An academic specialist, Satomi OGURA, has retired.
- (May/1) Dr. Naoki YAMADA has joined as a postdoctoral researcher.
- (Feb/1) Dr. Mao HORI has moved to Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University as an assistant professor.
- (Jan/31) Our original paper regarding “Effect of polypeptide hydrophobicity on antisense oligonucleotide delivery” has been published by Bioconjugate Chemistry.
- (Jan/16) Our review paper regarding “Endosomal escape of polyplexes” has been published by Macromolecular Bioscience.
≫ Macromolecular Bioscience
- (July/8) Our original paper regarding the polymeric nanoruler targeting brain tumor has been highlighted in EurekAlert!.
- 2023
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- (Dec/5) Our original paper regarding “Development of a biocompatible polymer alternative to PEG” has been accepted by Journal of Applied Polymer Science.
- (Sep/1) Assistant Professor Mitsuru Naito has been promoted to Lecturer.
- (Jun/24) Our review paper regarding "Polymer-based RNA delivery” has been published by Advanced Drug Delivery Reviews.
≫ Advanced Drug Delivery Reviews - (May/1) Dr. Jongmin YUM has moved to Department of Neurology and Neurological Science, Tokyo Medical & Dental University.
- 2022
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- (Dec/1) Prof. Kanjiro Miyata has become a cooperating faculty member of Department of Bioengineering.
- (Nov/19) Mr. Kohki Yamada (B4) has received Excellent Poster Award in 2022 International Graduate Symposium of Biopharmaceuticals. The presentation title is “Development of polymeric nanoparticles with precisely controlled PEG density for systemic mRNA delivery to the spleen”.
- (Nov/1) Our original paper regarding “Design of nanomaterials for X-ray-mediated photodynamic therapy” has been published by ACS Applied Bio Materials.
≫ ACS Applied Bio Materals - (Oct/1) Dr Mao HORI has joined as a postdoctoral researcher, and Ms. Heemin CHANG and Ms. Nan QIAO have joined as doctor course students.
- (May/31) Our research paper regarding muscle-targeted drug delivery has been highlighted on EurekAlert!.
≫ EurekAlert! - (May/20) Ms. Heemin CHANG has joined our laboratory as a research student.
- (May/20) Our original paper regarding “Muscle accumulation of size-tunable polymeric nanomaterials (termed nanoruler)” has been accepted by Journal of Controlled Release.
- (Apr/6) Dr Chun Yin (Jerry) LAU has joined our laboratory as a JSPS postdoctoral fellow.
- (Apr/4) New undergraduates and graduate have joined our laboratory.
- (Apr/1) Dr. Mitsuru Naito has arrived as an assistant professor in Department of Materials Engineering.
- (Mar/24) Mr. Jongmin Yum and Rimpei Kamegawa has completed their PhD study and obtained PhD (Engineering).
- (Mar/24) Mr. Rimpei Kamegawa (D3) has been commended as the chief graduate of the doctoral course in the Department of Materials Engineering.
- (Jan/1) Associate Professor Kanjiro Miyata has been promoted to Professor.
- 2021
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- (Dec/31) Our original paper regarding “Systemic mRNA delivery by cationic/hydrophobic polyaspartamide derivatives” has been accepted by Journal of Controlled Release.
- (Dec/6) Our original paper regarding “Effect of cationic chain length of Y-shaped block copolymers on the properties of siRNA-loaded unit polyion complexes” has been accepted by Biomacromolecules.
- (Nov/30) Mr. Jongmin Yum (D3) has received Excellent Poster Presentation at The 43rd Annual Meeting of the Japanese Society for Biomaterials & The 8th Asian Biomaterials Congress. The presentation title is Development of amphiphilic polyaspartamide derivatives for systemic messenger RNA delivery.
- (Oct/11) Our original paper regarding “Silica-coated polyion complexes for macrophage-targeted mRNA delivery” has been published by ACS Applied Bio Materials.
≫ Bioinspired Silicification of mRNA-Loaded Polyion Complexes for Macrophage-Targeted mRNA Delivery - (Oct/01) JSPS Postdoctoral Fellow Dr Debabrata Maiti has moved to Jikei University School of Medicine as a postdoctoral researcher.
- (Sep/24) Mr. Hiroyuki Chaya has completed his PhD study and obtained PhD (Engineering).
- (Apr/12) New undergraduate students have joined our laboratory.
- (Jan/03) Our original paper regarding "Unit polyion complexes loaded with chemically modified oligonucleotide drugs" has been accepted by Journal of Controlled Release.
- 2020
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- (Dec/04) Associate Prof Kanjiro Miyata has become an associate editor of Journal of Controlled Release, which is the official journal of the Controlled Release Society, and of the Japan Society of Drug Delivery System.
- (Sep/15) Our original paper regarding "Nanovesicles with antisense oligonucleotide as a membrane component and RNase H in the aqueous cavity for the simultaneous delivery" has been accepted by Biomacromolecules.
> Noncovalent stabilization of vesicular polyion complexes with chemically modified/single-stranded oligonucleotides and PEG-b-guanidinylated polypeptides for intracavity encapsulation of effector enzymes aimed at cooperative gene knockdown. - (Sep/01) Project Assistant Prof Hyun Jin Kim has moved to Inha University as an assistant professor (PI).
- (Aug/06) We have received The 2nd Materials and Devices Joint Research Award from the Network Joint Research Center & Dynamic Alliance. The research title is "Development of Polymeric Materials for Oligonucleotide Delivery (Foundational Joint Research Program)".
- (Jun/30) Our original paper regarding "Light-responsive oligonucleotide-embedded nanocapsule" has been accepted by Chemical Communications.
- (Apr/30) Our original paper regarding "Enhanced siRNA delivery by unit polyion complex with thermoresponsive hydrophobic domain" has been accepted by Bioconjugate Chemistry.
- (Apr/09) New undergraduate students have joined our laboratory.
- (Feb/17) Our research paper regarding "Antisense oligonucleotide-conjugated nanoparticle (ASOball) developed for enhanced gene knockdown in lung via intratracheal administration" has been selected as a cover picture in Advanced Therapeutics.
> Antisense oligonucleotide-conjugated nanoparticle (ASOball) developed for enhanced gene knockdown in lung via intratracheal administration - (Jan/27) Our original paper regarding "Glucose-installed polymeric micelles that can cross the blood-brain barrier for antisense oligonucleotide delivery to the brain" has been accepted by Angewandte Chemie International Edition.
- 2019
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- (Dec/16) Ms. Abhinaya SWAMINATHAN has joined our lab as an international internship trainee in Engineering School.
- (Oct/30) Mr. Hiroyuki Chaya (D2) has received ISNAC Outstanding Poster Award 2019 at The 46th International Symposium on Nucleic Acids Chemistry. The presentation title is Antisense oligonucleotide self-assemblies featuring improved physicochemical stability by chemical modification of nucleotides. The coauthors are Kotaro Hayashi, Shigeto Fukushima, Mitsuru Naito, Hyun Jin Kim, Kazunori Kataoka, and Kanjiro Miyata.
- (Oct/14) Our original paper regarding "Development of antisense oligonucleotide-decorated nanoparticle (ASOball) for intratracheal administration" has been accepted by Advanced Therapeutics.
- (Oct/02) Our original paper regarding "Messenger RNA delivery into the brain for gene editing" has been accepted by ACS Central Science.
- (Jul/30) Our original paper regarding "Thermo-responsive triblock copolymer micelles for antisense oligonucleotide delivery" has been accepted by ACS Biomaterials Science & Engineering.
- (Jul/16) Dr Debabrata MAITI has joined our lab as a JSPS postdoctoral fellow.
- (May/08) Mr. Rimpei Kamegawa (D1) has received Best Poster Presentation Award at 19th symposium for Gene Design and Delivery. The presentation title is Silica-coated polyion complexes as a messenger RNA carrier and application for oral delivery. The coauthors are Mitsuru Naito, Satoshi Uchida, Hyun Jin Kim, and Kanjiro Miyata.
- (Apr/26) Our nucleic acid delivery published by Nature Communications has been introduced by various media.
> Alpha Galileo (Apr/23)
New nanomedicine slips through the cracks - Nanomachines aim to deliver cancer drugs to hard-to-reach areas like the brain
> EurekAlert (Apr/24)
New nanomedicine slips through the cracks
> UTokyo Focus (Apr/24)
New nanomedicine slips through the cracks Nanomachines aim to deliver cancer drugs to hard-to-reach areas like the brain - (Apr/24) Our original paper regarding "small nucleic acid delivery to intractable cancers by unit polyion complex" has been published by Nature Communications.
> In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
> Bioengineer.org (Apr/24)
New nanomedicine slips through the cracks
> Science Daily (Apr/24)
New nanomedicine slips through the cracks, reaches brain: Nanomachines aim to deliver cancer drugs to hard-to-reach areas like the brain
> Phys.org (Apr/24)
New nanomedicine slips through the cracks
> ecancer (Apr/24)
New nanomedicine slips through the cracks
> Nanowerk (Apr/24)
New nanomedicine slips through the cracks
> Asian Scientist (May/10)
Nanomedicine Slips Through The Cracks To Fight Cancer - (Apr/09) New undergraduate students have joined our laboratory.
- (Apr/01) Mr. Rimpei Kamegawa (D1) has been adopted as a JSPS Research Fellow (DC1).
- (Apr/01) Dr Mitsuru Naito has been promoted to an assistant professor.
- (Feb/07) Our original paper regarding "vesicular polyion complex comprising siRNA-assembled membrane (siRNAsome)" has been accepted by Journal of the American Chemical Society.
> Self-assembly of siRNA/PEG-b-catiomer at integer molar ratio into 100 nm-sized vesicular polyion complexes (siRNAsomes) for RNAi and codelivery of cargo macromolecules - (Jan/07) Our original paper regarding "glucose ligand-installed siRNA delivery system for active cancer targeting" has been accepted by Journal of Controlled Release.
> Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells - (Jan/01) Dr Hyun Su Min moved to Biorchestra, a bioventure company.
- 2018
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- (Dec/21) JSPS Postdoctoral Fellow Beob Soo Kim has received Poster Award: Polymers Award at IPC2018. The presentation title is Vesicular self-assemblies from siRNAs and PEGylated block catiomers (siRNAsomes): Their structural, physicochemical, and biological characteristics. The coauthors are Kanjiro Miyata, Akihiro Kishimura, and Kazunori Kataoka.
- (Dec/17) Our original paper regarding "design of cationic polyasparagine derivatives for non-enzymatic degradation and messenger RNA delivery" has been accepted by Science & Technology of Advanced Materials (STAM).
> Tunable non-enzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency - (Dec/14) Assistant Professor Hyun Jin Kim has received Best Poster Award at the 5th COINS Symposium. The presentation title is Development of Amphiphilic Polymers for Cas9 mRNA Delivery. The coauthors are Kazunori Kataoka and Kanjiro Miyata.
- (Nov/13) Associate Professor Kanjiro Miyata has been awarded a Journal of Materials Chemistry B Presentation Prize at The 40th Annual Meeting of the Japanese Society for Biomaterials. The presentation title is Development of Vesicular Polyion Complexes from siRNAs and PEGylated Block Catiomers (siRNAsomes) for siRNA delivery. The coauthors are Beob Soo Kim, Sayan Chuanoi, Tomoya Suma, Yasutaka Anraku, Mitsuru Naito, Hyun Jin Kim, Akihiro Kishimura, Kazunori Kataoka.
- (Sep/21) A new PhD candidate has joined our laboratory.
- (Jul/01) Associate Professor Kanjiro Miyata has received the Nano Research Young Innovator Awards in NanoBiotech 2018. He is introduced by Nano Research.
- (Jun/30) Our review paper regarding polymeric micelles for nanomedicine applications has been published by Chemical Reviews.
> Block copolymer micelles in nanomedicine applications. - (Jun/05) Our review manuscript regarding siRNA delivery has been accepted by Biomacromolecules.
> Small delivery vehicles of siRNA for enhanced cancer targeting - (May/31) Our review paper regarding silica nanoparticle-based nucleic acid delivery has been accepted by Nano Research.
> Functionalization of silica nanoparticles for nucleic acid delivery. - (May/18) Our original paper regarding the antibody fragment-conjugated siRNA-loaded micelles has been accepted by Biomacromolecules.
> Tuned Density of Anti-Tissue Factor Antibody Fragment onto siRNA-loaded Polyion Complex Micelle for Optimizing Targetability into Pancreatic Cancer Cells - (Apr/10) New undergraduate students have joined our laboratory.
- 2017
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- (Dec/31) Dr Yu Yi moved to The National Center for Nanoscience and Technology (China) as a research associate.
- (Sep/01) Mr. HOGREL (M1) has joined our lab.
- (Aug/25) Ms. Katano has resigned from our lab.
- (Jul/07) A book written by Dr. Mitsuru Naito and associate professor Kanjiro Miyata as shared authors has been published from Technical Infromation Institute Co.;Ltd(ISBN978-4-86104-663-6).
The title is "Application development of DDS advanced technology to formulation". - (Jul/01) Dr Kim Beob Soo has joined our lab as a project postdoctoral researcher.
- (Jun/02) Associate Professor Kanjiro Miyata has received The Nucleic Acids Therapeutics Society of Japan (NatsJ) Award for Young Scientists.
- (Apr/11) New undergraduate students have joined our Lab.
- (Apr/01) Ms. Satomi OGURA has joined our Lab as a project academic support specialist.
- (Mar/01) Our original paper regarding the silica-coated nanoparticles for cancer-targeted siRNA delivery has been accepted by Journal of Biomaterials Science, Polymer Edition.
> Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery - (Jan/04) iCONM will hold the 11th Annual Symposium on Nanobiotechnology
Date: Feb. 27 (Mon.) & 28 (Tue.) 9:30am -(Registration starts at 8:30am)
Venue: Ground Floor & 4th Floor, Public Interest Incorporated Foundation, Kawasaki Institute of Industrial Promotion, Kawasaki City Industrial Promotion Hall
Language: English (No simultaneous interpretation)
Registration Fee: 3,000yen ※ Please register online.
The symposium website can be found here.
- 2016
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- (Dec/08) Our collaboration study "Glioma-targeted antisense oligonucleotide delivery" with Department of Epigenomics, Nagoya City University Graduate School of Medicine, has been published in Nature Communications.
> Targeting the notch-regulated non-coding RNA TUG1 for glioma treatment
> Japan Agency for Medical Research and Development (AMED) Press Release (Japanese)
> Nagoya City University Press Release (Japanese) - (Nov/01) Dr Yi Yu has joined our lab as a project postdoctoral researcher.
- (Oct/25) Our review paper regarding polymeric nanocarriers for small nucleic acid delivery has been accepted by Drug Discoveries & Therapeutics.
- (Sep/01) Dr Hyun Su MIN has received the JSPS Postdoctoral Fellowship for Overseas Researchers.
- (Aug/29) Our original paper regarding the targeted siRNA nanocarrier fabricated from cRGD-installed unimer polyion complexes and gold nanoparticle has been accepted by Journal of Controlled Release.
- (Jun/29) Our review paper regarding siRNA delivery has been accepted by Advanced Drug Delivery Reviews.
- (Apr/11) New undergraduate students have joined our laboratory.
- (Feb/03) We started a laboratory homepage.
- (Dec/08) Our collaboration study "Glioma-targeted antisense oligonucleotide delivery" with Department of Epigenomics, Nagoya City University Graduate School of Medicine, has been published in Nature Communications.