Is it possible to make anticancer drugs with no adverse side effects?

Does the gene therapy come true?

What is the cell therapy? What does it do?

To make the answer to these questions, this laboratory creates new nanomedical devices based on materials engineering. Particularly, we have developed polymeric nanomaterials for drug and nucleic acid delivery. To realize the nucleic acid therapy, nucleic acids need to be delivered to the cytoplasm of target cells by overcoming various biological barriers. Smart materials that can exert the desired function in response to the biological microenvironment enable the creation of nanodevices for successful nucleic acid delivery. The fun of this "NanoBio" research is that the outcome can be dramatically improved by a slight change in material design. Meanwhile, there are many issues in this research field to overcome for ideal cancer therapy and cell therapy. Let's enjoy the NanoBio research with us!

Jul/29/2021

Mr. Jongmin Yum (D3) has received Best Poster Award 1st Prize at the 48th Annual Meeting of the Controlled Release Society. The presentation title is “Development of amphiphilic polyaspartamide derivatives for systemic messenger RNA delivery to lung”.

Apr/12/2021

New undergraduate students have joined our laboratory.

Jan/03/2021

Our original paper regarding "Unit polyion complexes loaded with chemically modified oligonucleotide drugs" has been accepted by Journal of Controlled Release.

Dec/04/2020

Associate Prof Kanjiro Miyata has become an associate editor of Journal of Controlled Release, which is the official journal of the Controlled Release Society, and of the Japan Society of Drug Delivery System.

Sep/15/2020

Our original paper regarding "Nanovesicles with antisense oligonucleotide as a membrane component and RNase H in the aqueous cavity for the simultaneous delivery" has been accepted by Biomacromolecules.
▶ Noncovalent stabilization of vesicular polyion complexes with chemically modified/single-stranded oligonucleotides and PEG-b-guanidinylated polypeptides for intracavity encapsulation of effector enzymes aimed at cooperative gene knockdown.

Sep/01/2020

Project Assistant Prof Hyun Jin Kim has moved to Inha University as an assistant professor (PI).

Aug/06/2020

We have received The 2nd Materials and Devices Joint Research Award from the Network Joint Research Center & Dynamic Alliance. The research title is "Development of Polymeric Materials for Oligonucleotide Delivery (Foundational Joint Research Program)".

Jun/30/2020

Our original paper regarding "Light-responsive oligonucleotide-embedded nanocapsule" has been accepted by Chemical Communications.

Apr/30/2020

Our original paper regarding "Enhanced siRNA delivery by unit polyion complex with thermoresponsive hydrophobic domain" has been accepted by Bioconjugate Chemistry.

Apr/09/2020

New undergraduate students have joined our laboratory.

Feb/17/2020

Our research paper regarding "Antisense oligonucleotide-conjugated nanoparticle (ASOball) developed for enhanced gene knockdown in lung via intratracheal administration" has been selected as a cover picture in Advanced Therapeutics.
▶ Antisense oligonucleotide-conjugated nanoparticle (ASOball) developed for enhanced gene knockdown in lung via intratracheal administration

Jan/27/2020

Our original paper regarding "Glucose-installed polymeric micelles that can cross the blood-brain barrier for antisense oligonucleotide delivery to the brain" has been accepted by Angewandte Chemie International Edition.

Dec/16/2019

Ms. Abhinaya SWAMINATHAN has joined our lab as an international internship trainee in Engineering School.

Oct/30/2019

Mr. Hiroyuki Chaya (D2) has received ISNAC Outstanding Poster Award 2019 at The 46th International Symposium on Nucleic Acids Chemistry. The presentation title is Antisense oligonucleotide self-assemblies featuring improved physicochemical stability by chemical modification of nucleotides. The coauthors are Kotaro Hayashi, Shigeto Fukushima, Mitsuru Naito, Hyun Jin Kim, Kazunori Kataoka, and Kanjiro Miyata.

Oct/14/2019

Our original paper regarding "Development of antisense oligonucleotide-decorated nanoparticle (ASOball) for intratracheal administration" has been accepted by Advanced Therapeutics.

Oct/02/2019

Our original paper regarding "Messenger RNA delivery into the brain for gene editing" has been accepted by ACS Central Science.

Jul/30/2019

Our original paper regarding "Thermo-responsive triblock copolymer micelles for antisense oligonucleotide delivery" has been accepted by ACS Biomaterials Science & Engineering.

Jul/16/2019

Dr Debabrata MAITI has joined our lab as a JSPS postdoctoral fellow.

May/08/2019

Mr. Rimpei Kamegawa (D1) has received Best Poster Presentation Award at 19th symposium for Gene Design and Delivery. The presentation title is Silica-coated polyion complexes as a messenger RNA carrier and application for oral delivery. The coauthors are Mitsuru Naito, Satoshi Uchida, Hyun Jin Kim, and Kanjiro Miyata.

Apr/26/2019

Our nucleic acid delivery published by Nature Communications has been introduced by various media.
▶ Alpha Galileo (Apr/23)
New nanomedicine slips through the cracks - Nanomachines aim to deliver cancer drugs to hard-to-reach areas like the brain
▶ EurekAlert (Apr/24)
New nanomedicine slips through the cracks
▶ UTokyo Focus (Apr/24)
New nanomedicine slips through the cracks Nanomachines aim to deliver cancer drugs to hard-to-reach areas like the brain

Apr/24/2019

Our original paper regarding "small nucleic acid delivery to intractable cancers by unit polyion complex" has been published by Nature Communications.
▶ In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
▶ Bioengineer.org (Apr/24)
New nanomedicine slips through the cracks
▶ Science Daily (Apr/24)
New nanomedicine slips through the cracks, reaches brain: Nanomachines aim to deliver cancer drugs to hard-to-reach areas like the brain
▶ Phys.org (Apr/24)
New nanomedicine slips through the cracks
▶ ecancer (Apr/24)
New nanomedicine slips through the cracks
▶ Nanowerk (Apr/24)
New nanomedicine slips through the cracks
▶ Asian Scientist (May/10)
Nanomedicine Slips Through The Cracks To Fight Cancer

Apr/09/2019

New undergraduate students have joined our laboratory.

Apr/01/2019

Mr. Rimpei Kamegawa (D1) has been adopted as a JSPS Research Fellow (DC1).

Apr/01/2019

Dr Mitsuru Naito has been promoted to an assistant professor.

Feb/07/2019

Our original paper regarding "vesicular polyion complex comprising siRNA-assembled membrane (siRNAsome)" has been accepted by Journal of the American Chemical Society.
▶ Self-assembly of siRNA/PEG-b-catiomer at integer molar ratio into 100 nm-sized vesicular polyion complexes (siRNAsomes) for RNAi and codelivery of cargo macromolecules

Jan/07/2019

Our original paper regarding "glucose ligand-installed siRNA delivery system for active cancer targeting" has been accepted by Journal of Controlled Release.
▶ Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells

Jan/01/2019

Dr Hyun Su Min moved to Biorchestra, a bioventure company.

Dec/21/2018

JSPS Postdoctoral Fellow Beob Soo Kim has received Poster Award: Polymers Award at IPC2018. The presentation title is Vesicular self-assemblies from siRNAs and PEGylated block catiomers (siRNAsomes): Their structural, physicochemical, and biological characteristics. The coauthors are Kanjiro Miyata, Akihiro Kishimura, and Kazunori Kataoka.

Dec/17/2018

Our original paper regarding "design of cationic polyasparagine derivatives for non-enzymatic degradation and messenger RNA delivery" has been accepted by Science & Technology of Advanced Materials (STAM).
▶ Tunable non-enzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency

Dec/14/2018

Assistant Professor Hyun Jin Kim has received Best Poster Award at the 5th COINS Symposium. The presentation title is Development of Amphiphilic Polymers for Cas9 mRNA Delivery. The coauthors are Kazunori Kataoka and Kanjiro Miyata.

Nov/13/2018

Associate Professor Kanjiro Miyata has been awarded a Journal of Materials Chemistry B Presentation Prize at The 40th Annual Meeting of the Japanese Society for Biomaterials. The presentation title is Development of Vesicular Polyion Complexes from siRNAs and PEGylated Block Catiomers (siRNAsomes) for siRNA delivery. The coauthors are Beob Soo Kim, Sayan Chuanoi, Tomoya Suma, Yasutaka Anraku, Mitsuru Naito, Hyun Jin Kim, Akihiro Kishimura, Kazunori Kataoka.

Sep/21/2018

A new PhD candidate has joined our laboratory.

Jul/01/2018

Associate Professor Kanjiro Miyata has received the Nano Research Young Innovator Awards in NanoBiotech 2018. He is introduced by Nano Research.

Jun/30/2018

Our review paper regarding polymeric micelles for nanomedicine applications has been published by Chemical Reviews.
▶ Block copolymer micelles in nanomedicine applications.

Jun/05/2018

Our review manuscript regarding siRNA delivery has been accepted by Biomacromolecules.
▶ Small delivery vehicles of siRNA for enhanced cancer targeting

May/31/2018

Our review paper regarding silica nanoparticle-based nucleic acid delivery has been accepted by Nano Research.
▶ Functionalization of silica nanoparticles for nucleic acid delivery.

May/18/2018

Our original paper regarding the antibody fragment-conjugated siRNA-loaded micelles has been accepted by Biomacromolecules.
▶ Tuned Density of Anti-Tissue Factor Antibody Fragment onto siRNA-loaded Polyion Complex Micelle for Optimizing Targetability into Pancreatic Cancer Cells

Apr/10/2018

New undergraduate students have joined our laboratory.

Dec/31/2017

Dr Yu Yi moved to The National Center for Nanoscience and Technology (China) as a research associate.

Sep/01/2017

Mr. HOGREL (M1) has joined our lab.

Aug/25/2017

Ms. Katano has resigned from our lab.

Jul/07/2017

A book written by Dr. Mitsuru Naito and associate professor Kanjiro Miyata as shared authors has been published from Technical Infromation Institute Co.;Ltd(ISBN978-4-86104-663-6).
The title is "Application development of DDS advanced technology to formulation".

Jul/01/2017

Dr Kim Beob Soo has joined our lab as a project postdoctoral researcher.

Jun/02/2017

Associate Professor Kanjiro Miyata has received The Nucleic Acids Therapeutics Society of Japan (NatsJ) Award for Young Scientists.

Apr/11/2017

New undergraduate students have joined our Lab.

Apr/01/2017

Ms. Satomi OGURA has joined our Lab as a project academic support specialist.

Mar/01/2017

Our original paper regarding the silica-coated nanoparticles for cancer-targeted siRNA delivery has been accepted by Journal of Biomaterials Science, Polymer Edition.
▶ Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery

Jan/04/2017

iCONM will hold the 11th Annual Symposium on Nanobiotechnology
Date: Feb. 27 (Mon.) & 28 (Tue.) 9:30am -(Registration starts at 8:30am)
Venue: Ground Floor & 4th Floor, Public Interest Incorporated Foundation, Kawasaki Institute of Industrial Promotion, Kawasaki City Industrial Promotion Hall
Language: English (No simultaneous interpretation)
Registration Fee: 3,000yen ※ Please register online.
The symposium website can be found here.

Dec/08/2016

Our collaboration study "Glioma-targeted antisense oligonucleotide delivery" with Department of Epigenomics, Nagoya City University Graduate School of Medicine, has been published in Nature Communications.
▶ Targeting the notch-regulated non-coding RNA TUG1 for glioma treatment
▶ Japan Agency for Medical Research and Development (AMED) Press Release (Japanese)
▶ Nagoya City University Press Release (Japanese)

Nov/01/2016

Dr Yi Yu has joined our lab as a project postdoctoral researcher.

Oct/25/2016

Our review paper regarding polymeric nanocarriers for small nucleic acid delivery has been accepted by Drug Discoveries & Therapeutics.

Sep/01/2016

Dr Hyun Su MIN has received the JSPS Postdoctoral Fellowship for Overseas Researchers.

Aug/29/2016

Our original paper regarding the targeted siRNA nanocarrier fabricated from cRGD-installed unimer polyion complexes and gold nanoparticle has been accepted by Journal of Controlled Release.

Jun/29/2016

Our review paper regarding siRNA delivery has been accepted by Advanced Drug Delivery Reviews.

Apr/11/2016

New undergraduate students have joined our laboratory.

Feb/03/2016

We started a laboratory homepage.