[English]
- W. Yang, T. Miyazaki, P. Chen, T. Hong, M. Naito, Y. Miyahara, A. Matsumoto, K. Kataoka, K. Miyata, H. Cabral, Block catiomer with flexible cationic segment enhances complexation with siRNA and the delivery performance in vitro. Sci. Technol. Adv. Mater. in press
- T. Nagata, C. A. Dwyer, K. Yoshida-Tanaka, K. Ihara, M. Ohyagi, H. Kaburagi, H. Miyata, S. Ebihara, K. Yoshioka, T. Ishii, K. Miyata, K. Miyata, B. Powers, T. Igari, S. Yamamoto, N. Arimura, H. Hirabayashi, T. Uchihara, R. Iwata Hara, T. Wada, C. F. Bennett, P. P. Seth , F. Rigo, T. Yokota, Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS. Nat. Biotechnol. in press
- C. Wang, K. Kimura, J. Li, J. J. Richardson, M. Naito, K. Miyata, T. Ichiki, H. Ejima, Polydopamine-mediated surface functionalization of exosomes. ChemNanoMat 7 592-595 (2021) (DOI: 10.1002/cnma.202100078)
- Y. Tasaki, M. Suzuki, K. Katsushima, K. Shinjo, K. Iijima, Y. Murofushi, A. Naiki-Ito, K. Hayashi, C. Qiu, A. Takahashi, Y. Tanaka, T. Kawaguchi, M. Sugawara, T. Kataoka, M. Naito, K. Miyata, K. Kataoka, T. Noda, W. Gao, H. Kataoka, S. Takahashi, K. Kimura, Y. Kondo, Cancer-specific targeting of taurine upregulated gene 1 enhances the effects of chemotherapy in pancreatic cancer. Cancer Res. 81 1654-1666 (2021) (DOI: 10.1158/0008-5472.CAN-20-3021)
- M. Naito, H. Chaya, K. Toh, B. S. Kim, K. Hayashi, S. Fukushima, T. Nagata, T. Yokota, K. Kataoka, K. Miyata, Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(L-lysine). J. Control. Release 330 812-820 (2021) (DOI: 10.1016/j.jconrel.2021.01.001)
- B. S. Kim, M. Naito, H. Chaya, M. Hori, K. Hayashi, H. S. Min, Y. Yi, H. J. Kim, T. Nagata, Y. Anraku, A. Kishimura, K. Kataoka, K. Miyata, Noncovalent stabilization of vesicular polyion complexes with chemically modified/single-stranded oligonucleotides and PEG-b-guanidinylated polypeptides for intracavity encapsulation of effector enzymes aimed at cooperative gene knockdown. Biomacromolecules 21 (10) 4365-4376 (2020) (DOI: 10.1021/acs.biomac.0c01192)
- B. S. Kim, M. Naito, R. Kamegawa, H. J. Kim, R. Iizuka, T. Funatsu, S. Ueno, T. Ichiki, A. Kishimura, K. Miyata, Photo-reactive oligonucleotide-embedded nanovesicles (PROsomes) with switchable stability for efficient cellular uptake and gene knockdown. Chem. Commun. 56 Issue 66 9477-9480 (2020) (DOI: 10.1039/D0CC01750G)
- Y. Mitobe, K. Ikeda, W. Sato, Y. Kodama, M. Naito, N. Gotoh, K. Miyata, K. Kataoka, H. Sasaki, K. Horie-Inoue, S. Inoue, Proliferation‐associated long noncoding RNA, TMPO‐AS1 , is a potential therapeutic target for triple‐negative breast cancer. Cancer Sci. 111 Issue 7 2440-2450 (2020) (DOI: 10.1111/cas.14498)
- B. S. Kim, S. Osawa, J. Yum, M. Naito, K. Miyata, Installation of thermoswitchable hydrophobic domain into unimer polyion complex for enhanced cellular uptake of siRNA. Bioconjugate Chem. 31 (5) 1320-1326 (2020) (DOI: 10.1021/acs.bioconjchem.0c00238)
- H. S. Min, H. J. Kim, M. Naito, S. Ogura, K. Toh, K. Hayashi, B. S. Kim, S. Fukushima, Y. Anraku, K. Miyata, K. Kataoka, Systemic brain delivery of antisense oligonucleotides across the blood‐brain barrier with a glucose‐installed polymeric nanocarrier. Angew. Chem. Int. Ed. 59 Issue 21 8173-8180 (2020) (DOI: 10.1002/anie.201914751)
- B. S. Kim, S. Osawa, M. Naito, S. Ogura, R. Kamegawa, H. Ishida, H. J. Kim, S. Uchida, K. Miyata, A 50 nm-sized micellar assembly of thermoresponsive polymer-antisense oligonucleotide conjugates for enhanced gene knockdown in lung cancer by intratracheal administration. Adv. Therap. 3 1900123 (2020) (DOI: 10.1002/adtp.201900123)
- H. J. Kim, S. Ogura, T. Otabe, R. Kamegawa, M. Sato, K. Kataoka, K. Miyata, Fine-tuning of hydrophobicity in amphiphilic polyaspartamide derivatives for rapid and transient expression of messenger RNA directed toward genome engineering in brain. ACS Cent. Sci. 5 Issue11 1866-1875 (2019) (DOI: 10.1021/acscentsci.9b00843)
- B. S. Kim, H. J. Kim, S. Osawa, K. Hayashi, K. Toh, M. Naito, H. S. Min, Y. Yi, I. C. Kwon, K. Kataoka, K. Miyata, Dually stabilized triblock copolymer micelles with hydrophilic shell and hydrophobic interlayer for systemic antisense oligonucleotide delivery to solid tumor. ACS Biomater. Sci. Eng. 5 Issue11 5770-5780 (2019) (DOI: 10.1021/acsbiomaterials.9b00384)
- S. Watanabe, K. Hayashi, K. Toh, H. J. Kim, X. Liu, H. Chaya, S. Fukushima, K. Katsushima, Y. Kondo, S. Uchida, S. Ogura, T. Nomoto, H. Takemoto, H. Cabral, H. Kinoh, H. Tanaka, M. R. Kano, Y. Matsumoto, H. Fukuhara, S. Uchida, M. Nangaku, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka, In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancer. Nat. Commun. 10 1894 (2019) (DOI: 10.1038/s41467-019-09856-w)
- T. Takai, T. Tsujino, Y. Yoshikawa, T. Inamoto, N. Sugito, Y. Kuranaga, T. Soga, K. Hayashi, K. Miyata, K. Kataoka, H. Azuma, Y. Akao, Synthetic miR-143 exhibited an anti-cancer effect via downregulation of K-RAS networks of renal cell cancer cells in vitro and in vivo. Mol. Ther. 27 (5) 1-11 (2019) (DOI: 10.1016/j.ymthe.2019.03.004)
- Y. Yoshikawa, K. Taniguchi, T. Tsujino, K. Heishima, T. Inamoto, T. Takai, K. Minami, H. Azuma, K. Miyata, K. Hayashi, K. Kataoka, Y. Akao, Anti-cancer effects of a chemically modified miR-143 on bladder cancer by either systemic or intravesical treatment. Mol. Ther. Methods Clin. Dev. 13 290-302 (2019) (DOI: 10.1016/j.omtm.2019.02.005)
- B. S. Kim, S. Chuanoi, T. Suma, Y. Anraku, K. Hayashi, M. Naito, H. J. Kim, I. C. Kwon, K. Miyata, A. Kishimura, K. Kataoka, Self-assembly of siRNA/PEG-b-catiomer at integer molar ratio into 100 nm-sized vesicular polyion complexes (siRNAsomes) for RNAi and codelivery of cargo macromolecules. J. Am. Chem. Soc. 141 (8) 3699-3709 (2019) (DOI: 10.1021/jacs.8b13641)
- M. Naito, Y. Otsu, R. Kamegawa, K. Hayashi, S. Uchida, H. J. Kim, K. Miyata, Tunable non-enzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency. Sci. Technol. Adv. Mater. 20 (1) 105-115 (2019) (DOI: 10.1080/14686996.2019.1569818)
- Y. Yi, H. J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka, Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J. Control. Release 295 268-277 (2019) (DOI: 10.1016/j.jconrel.2019.01.006)
- H. S. Min, H. J. Kim, J. Y. Ahn, M. Naito, K. Hayashi, K. Toh, B. S. Kim, Y. Matsumura, I. C. Kwon, K. Miyata, K. Kataoka, Tuned density of anti-tissue factor antibody fragment onto siRNA-loaded polyion complex micelle for optimizing targetability into pancreatic cancer cells. Biomacromolecules 19 (6) 2320-2329 (2018) (DOI: 10.1021/acs.biomac.8b00507)
- M. Naito, N. Yoshinaga, T. Ishii, A. Matsumoto, Y. Miyahara, K. Miyata, K. Kataoka, Enhanced intracellular delivery of siRNA by controlling ATP-responsivity of phenylboronic acid-functionalized polyion complex micelles. Macromol. Biosci. 18 (1) 1700357 (2018) (DOI: 10.1002/mabi.201700357)
- Y. Zou, M. Zheng, W. Yang, F. Meng, K. Miyata, H. J. Kim, K. Kataoka, Z. Zhong, Virus-mimicking chimaeric polymersomes boost targeted cancer siRNA therapy in vivo. Adv. Mater. 29 Issue42 1703285 (2017) (DOI: 10.1002/adma.201703285)
- Y. Anraku, H. Kuwahara, Y. Fukusato, A. Mizoguchi, T. Ishii, K. Nitta, Y. Matsumoto, K. Toh, K. Miyata, S. Uchida, K. Nishina, K. Osada, K. Itaka, N. Nishiyama, H. Mizusawa, T. Yamasoba, T. Yokota, K. Kataoka, Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nat. Commun. 8 1001 (2017) (DOI: 10.1038/s41467-017-00952-3)
- K. Klinker, O. Schäfer, D. Huesmann, T. Bauer, L. Capelôa, L. Braun, N. Stergiou, M. Schinnerer, A. Dirisala, K. Miyata, K. Osada, H. Cabral, K. Kataoka, M. Barz, Secondary structure-driven self-assembly of reactive polypept(o)ides: Controlling size, shape and function of core cross-linked nanostructures. Angew. Chem. Int. Ed. 56 (32) 9608-9613 (2017) (DOI: 10.1002/anie.201702624)
- M. Naito, R. Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H. J. Kim, T. Ishii, N. Nishiyama, K. Miyata, K. Kataoka, Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery. J. Biomater. Sci. Polym. Ed. 28 Issue10-12 1109-1123 (2017) (DOI: 10.1080/09205063.2017.1301775)
- C. Moriya, H. Taniguchi, K. Miyata, N. Nishiyama, K. Kataoka, K. Imai, Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice. Carcinogenesis 38 (6) 638-648 (2017) (DOI: 10.1093/carcin/bgx040)
- Y. Yi, H. J. Kim, P. Mi, M. Zheng, H. Takemoto, K. Toh, B. S. Kim, K. Hayashi, M. Naito, Y. Matsumoto, K. Miyata, K. Kataoka, Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles. J. Control. Release 244 PartB 247-256 (2016) (DOI: 10.1016/j.jconrel.2016.08.041)
The 14th edition of the European Symposium on Controlled Drug Delivery, Egmond aan Zee, The Netherlands on April 13-15, 2016
- K. Katsushima, A. Natsume, F. Ohta, K. Shinjo, A. Hatanaka, N. Ichimura, S. Sato, S. Takahashi, H. Kimura, Y. Totoki, T. Shibata, M. Naito, H. J. Kim, K. Miyata, K. Kataoka, Y. Kondo, Targeting the notch-regulated non-coding RNA TUG1 for glioma treatment. Nat. Commun. 7 13616 (2016) (DOI: 10.1038/ncomms13616)
- H. Nishida, Y. Matsumoto, K. Kawana, R. J. Christie, M. Naito, B. S. Kim, K. Toh, H. S. Min, Y. Yi, Y. Matsumoto, H. J. Kim, K. Miyata, A. Taguchi, K. Tomio, A. Yamashita, T. Inoue, H. Nakamura, A. Fujimoto, M. Sato, M. Yoshida, K. Adachi, T. Arimoto, O. Wada-Hiraike, K. Oda, T. Nagamatsu, N. Nishiyama, K. Kataoka, Y. Osuga, T. Fujii, Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes. J. Control. Release 231 29-37 (2016) (DOI: 10.1016/j.jconrel.2016.03.016)
- F. Perche, Y. Yi, L. Hespel, P. Mi, A. Dirisala, H. Cabral, K. Miyata, K. Kataoka, Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity. Biomaterials 90 62-71 (2016) (DOI: 10.1016/j.biomaterials.2016.02.027)
- K. Hayashi, H. Chaya, S. Fukushima, S. Watanabe, H. Takemoto, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka, Influence of RNA strand rigidity on polyion complex formation with block catiomers. Macromol. Rapid Commun. 37 (6) 486-493 (2016) (DOI: 10.1002/marc.201500661)
- H. Uchida, K. Itaka, S. Uchida, T. Ishii, T. Suma, K. Miyata, M. Oba, N. Nishiyama, K. Kataoka, Synthetic polyamines to regulate mRNA translation through the preservative binding of eukaryotic initiation factor 4E to the cap structure. J. Am. Chem. Soc. 138 (5) 1478-1481 (2016) (DOI: 10.1021/jacs.5b11726)
- T. Ishii, K. Miyata, Y. Anraku, M. Naito, Y. Yi, T. Jinbo, S. Takae, Y. Fukusato, M. Hori, K. Osada, K. Kataoka, Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths. Chem. Commun. 52 (7) 1517-1519 (2016) (DOI: 10.1039/C5CC06661A)
- M. Tangsangasaksri, H. Takemoto, M. Naito, Y. Maeda, D. Sueyoshi, H. J. Kim, Y. Miura, J. Y. Ahn, R. Azuma, N. Nishiyama, K. Miyata, K. Kataoka, siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting enhanced RNAi efficacy. Biomacromolecules 17 (1) 246-255 (2016) (DOI: 10.1021/acs.biomac.5b01334)
- Y. Nomura, M. Kaneko, K. Miyata, Y. Yatomi, Y. Yanagi, Bevacizumab and aflibercept activate platets via Fc RIIa. Invest. Ophthal. Vis. Sci. 56 (13) 8075-8082 (2015) (DOI: 10.1167/iovs.15-17814)
- M. Murakami, K. Nishina, C. Watanabe, K. Y. Tanaka, W. Piao, H. Kuwahara, Y. Horikiri, K. Miyata, N. Nishiyama, K. Kataoka, M. Yoshida, H. Mizusawa, T. Yokota, Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route. Sci. Rep. 5 17035 (2015) (DOI: 10.1038/srep17035)
- K. Nishina, W. Piao, K. Y-Tanaka, Y. Sujino, T. Nishina, T. Yamamoto, K. Nitta, K. Yoshioka, H. Kuwahara, H. Yasuhara, T. Baba, F. Ono, K. Miyata, K. Miyake, P. P. Seth, A. Low, M. Yoshida, C. F. Bennett, K. Kataoka, H. Mizusawa, S. Obika, T. Yokota, DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. Nat. Commun. 6 7969 (2015) (DOI: 10.1038/ncomms8969)
- H. Ogawa, X. Wu, K. Kawamoto, N. Nishida, M. Konno, J. Koseki, H. Matsui, K. Noguchi, N. Gotoh, T. Yamamoto, K. Miyata, N. Nishiyama, H. Nagano, H. Yamamoto, S. Obika, K. Kataoka, Y. Doki, M. Mori, H. Ishii, MicroRNAs induce epigenetic reprogramming and suppress malignant phenotypes of human colon cancer cells. PLOS ONE 10(5) e0127119 (2015) (DOI: 10.1371/journal.pone.0127119)
- H. Gao, H. Takemoto, Q. Chen, M. Naito, H. Uchida, X. Liu, K. Miyata, K. Kataoka, Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity. Chem. Commun. 51 (15) 3158-3161 (2015) (DOI: 10.1039/C4CC09859E)
- L. Nuhn, S. Tomcin, K. Miyata, V. Mailander, K. Landfester, K. Kataoka, R. Zentel, Size-dependent knockdown potential of siRNA-loaded cationic nanohydrogel particles. Biomacromolecules 15 (11) 4111-4121 (2014) (DOI: 10.1021/bm501148y)
- H. J. Kim, H. Takemoto, Y. Yi, M. Zheng, Y. Maeda, H. Chaya, K. Hayashi, P. Mi, F. Pittella, R. J. Christie, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka, Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles. ACS Nano 8 (9) 8979-8991 (2014) (DOI: 10.1021/nn502125h)
- H. Uchida, K. Itaka, T. Nomoto, T. ishii, T. Suma, M. Ikegami, K. Miyata, M. Oba, N. Nishiyama, K. Kataoka, Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection. J. Am. Chem. Soc. 136 (35) 12396-12405 (2014) (DOI: 10.1021/ja506194z) Selected as Spotlights of JACS
- Y. Oe, R. J. Christie, M. Naito, S. A. Low, S. Fukushima, K. Toh, Y. Miura, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka, Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors. Biomaterials 35 27 7887-7895 (2014) (DOI: 10.1016/j.biomaterials.2014.05.041)
- Y. Maeda, F. Pittella, T. Nomoto, H. Takemoto, N. Nishiyama, K. Miyata, K. Kataoka, Fine-tuning of charge-conversion polymer structure for efficient endosomal escape of siRNA-loaded calcium phosphate hybrid micelles. Macromol. Rapid Commun. 35 (13) 1211-1215 (2014) (DOI: 10.1002/marc.201400049)
- A. Dirisala, K. Osada, Q. Chen, T. A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka, K. Kataoka, Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials 35 (20) 5359-5368 (2014) (DOI: 10.1016/j.biomaterials.2014.03.037)
- L. Nuhn, S. Gietzen, K. Mohr, K. Fischer, K. Toh, K. Miyata, Y. Matsumoto, K. Kataoka, M. Schmidt, R. Zentel, Aggregation behavior of cationic nanohydrogel particles in human blood serum. Biomacromolecules 15 (4) 1526-1533 (2014) (DOI: 10.1021/bm500199h)
- S. Murayama, P. Kos, K. Miyata, K. Kataoka, E. Wagner, M. Kato, Gene regulation by intracellular delivery and photodegradation of nanoparticles containing small interfering RNA. Macromol. Biosci. 14 (5) 626-631 (2014) (DOI: 10.1002/mabi.201300393)
- H. J. Kim, K. Miyata, T. Nomoto, M. Zheng, A. Kim, X. Liu, H. Cabral, R. J. Christie, N. Nishiyama, K. Kataoka, siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials 35 (15) 4548-4556 (2014) (DOI: 10.1016/j.biomaterials.2014.02.016)
- T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, Arnida, Y. Matsumoto, M. Oba, K. Miyata, K. Osada, N. Nishiyama, K. Kataoka, Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer. Nat. Commun. 5 3545 (2014) (DOI: 10.1038/ncomms4545)
- F. Pittella, H. Cabral, Y. Maeda, P. Mi, S. Watanabe, H. Takemoto, H. J. Kim, N. Nishiyama, K. Miyata, K. Kataoka, Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles. J. Control. Release 178 18-24 (2014) (DOI: 10.1016/j.jconrel.2014.01.008)
- H. J. Kim, T. Ishii, M. Zheng, S. Watanabe, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka, Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer. Drug Deliv. Transl. Res. 4 (1) 50-60 (2014) (DOI: 10.1007/s13346-013-0175-6)
- S. Biswas, K. Kinbara, T. Niwa, H. Taguchi, N. Ishii, S. Watanabe, K. Miyata, K. Kataoka, T. Aida, Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP. Nat. Chem. 5 613-620 (2013) (DOI: 10.1038/NCHEM.1681)
- H. Takemoto, K. Miyata, S. Hattori, T. Ishii, T. Suma, S. Uchida, N. Nishiyama, K. Kataoka, Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response. Angew. Chem. Int. Ed. 52 (24) 6218-6221 (2013) (DOI: 10.1002/anie.201300178)
- S. Wu, V. Kasim, M. R. Kano, S. Tanaka, S. Ohba, Y. Miura, K. Miyata, X. Liu, A. Matsuhashi, U. -l. Chung, K. Kataoka, N. Nishiyama, M. Miyagishi, Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner. Cancer Res. 73 (6) 1787-1799 (2013) (DOI: 10.1158/0008-5472.CAN-12-0366)
- N. Gouda, K. Miyata, R. J. Christie, T. Suma, A. Kishimura, S. Fukushima, T. Nomoto, X. Liu, N. Nishiyama, K. Kataoka, Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA. Biomaterials 34 (2) 562-570 (2013) (DOI: 10.1016/j.biomaterials.2012.09.077)
- M. Naito, T. Ishii, A. Matsumoto, K. Miyata, Y. Miyahara, K. Kataoka, A phenylboronate-functionalized polyion complex micelle for ATP-triggered release of siRNA. Angew. Chem. Int. Ed. 51 (43) 10751-10755 (2012) (DOI: 10.1002/anie.201203360)
- M. Sanjoh, K. Miyata, R. J. Christie, T. Ishii, Y. Maeda, F. Pittella, S. Hiki, N. Nishiyama, K. Kataoka, Dual environment-responsive polyplex carriers for enhanced intracellular delivery of plasmid DNA. Biomacromolecules 13 (11) 3641-3649 (2012) (DOI: 10.1021/bm301095a)
- T. Suma, K. Miyata, Y. Anraku, S. Watanabe, R. J. Christie, H. Takemoto, M. Shioyama, N. Gouda, T. Ishii, N. Nishiyama, K. Kataoka, Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG. ACS Nano 6 (8) 6693-6705 (2012) (DOI: 10.1021/nn301164a)
- F. Pittella, K. Miyata, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R. J. Christie, K. Osada, N. Nishiyama, K. Kataoka, Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles. J. Control. Release 161 (3) 868-874 (2012) (DOI: 10.1016/j.jconrel.2012.05.005)
- H. Takemoto, K. Miyata, T. Ishii, S. Hattori, S. Osawa, N. Nishiyama, K. Kataoka, Accelerated polymer-polymer click conjugation by freeze-thaw treatment. Bioconjugate Chem. 23 (8) 1503-1506 (2012) (DOI: 10.1021/bc300182y)
- R. J. Christie, Y. Matsumoto, K. Miyata, T. Nomoto, S. Fukushima, K. Osada, J. Halnaut, F. Pittella, H. J. Kim, N. Nishiyama, K. Kataoka, Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection. ACS Nano 6 (6) 5174-5189 (2012) (DOI: 10.1021/nn300942b)
- T. Suma, K. Miyata, T. Ishii, S. Uchida, H. Uchida, K. Itaka, N. Nishiyama, K. Kataoka, Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain. Biomaterials 33 (9) 2770-2779 (2012) (DOI: 10.1016/j.biomaterials.2011.12.022)
- H. J. Kim, M. Oba, F. Pittella, T. Nomoto, H. Cabral, Y. Matsumoto, K. Miyata, N. Nishiyama, K. Kataoka, PEG-detachable cationic polyaspartamide derivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor. J. Drug Target. 20 (1) 33-42 (2012) (DOI: 10.3109/1061186X.2011.632010)
- F. M. Mickler, Y. Vachutinsky, M. Oba, K. Miyata, N. Nishiyama, K. Kataoka, C. Brachle, N. Ruthardt, Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging. J. Control. Release 156 (3) 364-373 (2011) (DOI: 10.1016/j.jconrel.2011.08.003)
- A. Iriyama, T. Usui Y. Yanagi, S. Amano M. Oba, K. Miyata, N. Nishiyama, K. Kataoka, Gene transfer using micellar nanovectors inhibits corneal neovascularization in vivo. Cornea 30 (12) 1423-1427 (2011) (DOI: 10.1097/ICO.0b013e318206c893)
- S. Uchida, K. Itaka, Q. Chen, K. Osada, K. Miyata, T. Ishii, M. Harada-Shiba, K. Kataoka, Combination of chondroitin sulfate and polyplex micelles from poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity. J. Control. Release 155 (2) 296-302 (2011) (DOI: 10.1016/ j.jconrel.2011.04.026)
- H. Uchida, K. Miyata, M. Oba, T. Ishii, T. Suma, K. Itaka, N. Nishiyama, K. Kataoka, Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles. J. Am. Chem. Soc. 133 (39) 15524-15532 (2011) (DOI: 10.1021/ja204466y)
- R. J. Christie, K. Miyata, Y. Matsumoto, T. Nomoto, D. Menasco, T. -C. Lai, M. Pennisi, K. Osada, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka, Effect of polymer structure on micelles formed between siRNA and cationic block copolymer comprising thiols and amidines. Biomacromolecules 12 (9) 3174-3185 (2011) (DOI: 10.1021/bm2006714)
- Y. Uno, W. Piao, K. Miyata, K. Nishina, H. Mizusawa, T. Yokota, HDL facilitates in vivo delivery of a-tocopherol-conjugated siRNA to the brain. Hum. Gene Ther. 22 (6) 711-719 (2011) (DOI: 10.1089/hum.2010.083.)
- T. Nomoto, Y. Matsumoto, K. Miyata, M. Oba, S. Fukushima, N. Nishiyama, T. Yamasoba, K. Kataoka, In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy. J. Control. Release 151 (2) 104-109 (2011) (DOI: 10.1016/j.jconrel.2011.02.011)
- F. Pittella, M. Zhang, Y. Lee, H. J. Kim, T. Tockary, K. Osada, T. Ishii, K. Miyata, N. Nishiyama, K. Kataoka, Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity. Biomaterials 32 (11) 3106-3114 (2011) (DOI: 10.1016/j.biomaterials.2010.12.057)
- M. Oba, K. Miyata, K. Osada, R. J. Christie, M. Sanjoh, W. Li, S. Fukushima, T. Ishii, M. R. Kano, N. Nishiyama, H. Koyama, K. Kataoka, Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery. Biomaterials 32 (2) 652-663 (2011) (DOI: 10.1016/j.biomaterials.2010.09.022)
- Y. Vachutinsky, M. Oba, K. Miyata, S. Hiki, M. R. Kano, N. Nishiyama, H. Koyama, K. Miyazono, K. Kataoka, Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles. J. Control. Release 149 (1) 51-57 (2011) (DOI: 10.1016/j.jconrel.2010.02.002)
- H. Takemoto, A. Ishii, K. Miyata, M. Nakanishi, M. Oba, T. Ishii, Y. Yamasaki, N. Nishiyama, K. Kataoka, Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system. Biomaterials 31 (31) 8097-8105 (2010) (DOI: 10.1016/j.biomaterials. 2010.07.015)
- Y. Matsumoto, T. Nomoto, H. Cabral, Y. Matsumoto, S. Watanabe, R. J. Christie, K. Miyata, M. Oba, T. Ogura, Y. Yamasaki, N. Nishiyama, T. Yamasoba, K. Kataoka, Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography. Biomed. Opt. Express 1 (4) 1209-1216 (2010) (DOI: 10.1364/BOE. 1.001209)
- H. J. Kim, A. Ishii, K. Miyata, Y. Lee, S. Wu, M. Oba, N. Nishiyama, K. Kataoka, Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown. J. Control. Release 145 (2) 141-148 (2010) (DOI: 10.1016/j.jconrel.2010.03.019)
- M. Sanjoh, S. Hiki, Y. Lee, M. Oba, K. Miyata, T. Ishii, K. Kataoka, pDNA/poly(L-lysine) polyplexes functionalized with a pH-Sensitive charge-conversional poly(aspartamide) derivative for controlled gene delivery to human umbilical vein endothelial cells. Macromol. Rapid Commun. 31 (13) 1181-1186 (2010) (DOI: 10.1002/marc.201000056)
- K. Miyata, N. Gouda, H. Takemoto, M. Oba, Y. Lee, H. Koyama, Y. Yamasaki, K. Itaka, N. Nishiyama, K. Kataoka, Enhanced transfection with silica-coated polyplexes loading plasmid DNA. Biomaterials 31 (17) 4764-4770 (2010) (DOI: 10.1016/j.biomaterials.2010.02.033)
- M. Oba, Y. Vachutinsky, K. Miyata, M. R. Kano, S. Ikeda, N. Nishiyama, K. Itaka, K. Miyazono, H. Koyama, K. Kataoka, Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1. Mol. Pharmaceut. 7 (2) 501-509 (2010) (DOI: 10.1021/mp9002317)
- H. Shimizu, Y. Hori, S. Kaname, K. Yamada, N. Nishiyama, S. Matsumoto, K. Miyata, M. Oba, A. Yamada, K. Kataoka, T. Fujita, siRNA-based therapy ameliorates glomerulonephritis. J. Am. Soc. Nephrol. 21 (4) 622-633 (2010) (DOI: 10.1681/ASN.2009030295)
- M. Harada-Shiba, I. Takamisawa, K. Miyata, T. Ishii, N. Nishiyama, K. Itaka, K. Kangawa, F. Yoshihara, Y. Asada, K. Hatakeyama, N. Nagaya, K. Kataoka, Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats. Mol. Ther. 17 (7) 1180-1186 (2009) (DOI: 10.1038/mt.2009.63)
- S. Matsumoto, R. J. Christie, N. Nishiyama, K. Miyata, A. Ishii, M. Oba, H. Koyama, Y. Yamasaki, K. Kataoka, Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery. Biomacromolecules 10 (1) 119-127 (2009) (DOI: 10.1021/bm800985e)
- K. Miyata, M. Oba, M. Nakanishi, S. Fukushima, Y. Yamasaki, H. Koyama, N. Nishiyama, K. Kataoka, Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity. J. Am. Chem. Soc. 130 (48) 16287-16294 (2008) (DOI: 10.1021/ja804561g)
- K. Miyata, M. Oba, M. R. Kano, S. Fukushima, Y. Vachutinsky, M. Han, H. Koyama, K. Miyazono, N. Nishiyama, K. Kataoka, Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor. Pharm. Res. 25 (12) 2924-2936 (2008) (DOI: 10.1007/s11095-008-9720-2)
- M. Oba, K. Aoyagi, K. Miyata, Y. Matsumoto, K. Itaka, N. Nishiyama, Y. Yamasaki, H. Koyama, K. Kataoka, Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking. Mol. Pharmaceut. 5 (6) 1080-1092 (2008) (DOI: 10.1021/mp800070s)
- Y. Lee, K. Miyata, M. Oba, T. Ishii, S. Fukushima, M. Han, H. Koyama, N. Nishiyama, K. Kataoka, Charge-conversion ternary polyplex with endosome disruption moiety: A technique for efficient and safe gene delivery. Angew. Chem. Int. Ed. 47 (28) 5163-5166 (2008) (DOI: 10.1002/anie.200800963)
- S. Takae, K. Miyata, M. Oba, T. Ishii, N. Nishiyama, K. Itaka, Y. Yamasaki, H. Koyama, K. Kataoka, PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors. J. Am. Chem. Soc. 130 (18) 6001-6009 (2008) (DOI: 10.1021/ja800336v)
- K. Miyata, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka, PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy. J. Control. Release 122 (3) 252-260 (2007) (DOI: 10.1016/j.jconrel.2007.06.020)
- K. Itaka, S. Ohba, K. Miyata, H. Kawaguchi, K. Nakamura, T. Takato, U. -I. Chung, K. Kataoka, Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol. Ther. 15 (9) 1655-1662 (2007) (DOI: 10.1038/sj.mt.6300218)
- M. Han, Y. Bae, N. Nishiyama, K. Miyata, M. Oba, K. Kataoka, Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies. J. Control. Release 121 (1-2) 38-48 (2007) (DOI: 10.1016/j.jconrel.2007.05.012)
- N. Nishiyama, Arnida, W. -D. Jang, K. Date, K. Miyata, K. Kataoka, Photochemical enhancement of transgene expression by polymeric micelles incorporating plasmid DNA and dendrimer-based photosensitizer. J. Drug Target. 14 (6) 413-424 (2006) (DOI: 10.1080/10611860600834508)
- N. Kanayama, S. Fukushima, N. Nishiyama, K. Itaka, W. -D. Jang, K. Miyata, Y. Yamasaki, U. -I. Chung, K. Kataoka, A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells. ChemMedChem. 1 (4) 439-444 (2006) (DOI: 10.1002/cmdc.200600008)
- K. Miyata, Y. Kakizawa, N. Nishiyama, Y. Yamasaki, T. Watanabe, M. Kohara, K. Kataoka, Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelles with disulfide crosslinked cores to the liver. J. Control. Release 109 (1-3) 15-23 (2005) (DOI: 10.1016/j.jconrel.2005.09.043)
- N. Nishiyama, A. Iriyama, W. -D. Jang, K. Miyata, K. Itaka, Y. Inoue, H. Takahashi, Y. Yanagi, Y. Tamaki, H. Koyama, K. Kataoka, Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer. Nat. Mater. 4 (12) 934-941 (2005) (DOI: 10.1038/nmat1524)
- S. Fukushima, K. Miyata, N. Nishiyama, N. Kanayama, Y. Yamasaki, K. Kataoka, PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery. J. Am. Chem. Soc. 127 (9) 2810-2811 (2005) (DOI: 10.1021/ja0440506)
- D. Wakebayashi, N. Nishiyama, K. Itaka, K. Miyata, Y. Yamasaki, A. Harada, H. Koyama, Y. Nagasaki, K. Kataoka, Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficacy. Biomacromolecules 5 (6) 2128-2136 (2004) (DOI: 10.1021/bm040009j)
- Y. Kakizawa, K. Miyata, S. Furukawa, K. Kataoka, Size-controlled formation of a calcium phosphate-based organic-inorganic hybrid vector for gene delivery using poly(ethylene glycol)-block-poly(aspartic acid). Adv. Mater. 16 (8) 699-702 (2004) (DOI: 10.1002/adma.200305782)
- K. Miyata, Y. Kakizawa, N. Nishiyama, A. Harada, Y. Yamasaki, H. Koyama, K. Kataoka, Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. J. Am. Chem. Soc. 126 (8) 2355-2361 (2004) (DOI: 10.1021/ja0379666)
Miyata laboratory
The University of Tokyo, Department of Materials Engineering, Bld.#4, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656