Dec. 7 2019 Updated


  1. B. S. Kim, S. Osawa, M. Naito, S. Ogura, R. Kamegawa, H. Ishida, H. J. Kim, S. Uchida, K. Miyata, A 50 nm-sized micellar assembly of thermoresponsive polymer-antisense oligonucleotide conjugates for enhanced gene knockdown in lung cancer by intratracheal administration. Adv. Therap. in press.
  2. H. J. Kim, S. Ogura, T. Otabe, R. Kamegawa, M. Sato, K. Kataoka, K. Miyata, Fine-tuning of hydrophobicity in amphiphilic polyaspartamide derivatives for rapid and transient expression of messenger RNA directed toward genome engineering in brain. ACS Cent. Sci. 5 Issue11 1866-1875 (2019) (DOI: 10.1021/acscentsci.9b00843)
  3. B. S. Kim, H. J. Kim, S. Osawa, K. Hayashi, K. Toh, M. Naito, H. S. Min, Y. Yi, I. C. Kwon, K. Kataoka, K. Miyata, Dually stabilized triblock copolymer micelles with hydrophilic shell and hydrophobic interlayer for systemic antisense oligonucleotide delivery to solid tumor. ACS Biomater. Sci. Eng. 5 Issue11 5770-5780 (2019) (DOI: 10.1021/acsbiomaterials.9b00384)
  4. S. Watanabe, K. Hayashi, K. Toh, H. J. Kim, X. Liu, H. Chaya, S. Fukushima, K. Katsushima, Y. Kondo, S. Uchida, S. Ogura, T. Nomoto, H. Takemoto, H. Cabral, H. Kinoh, H. Tanaka, M. R. Kano, Y. Matsumoto, H. Fukuhara, S. Uchida, M. Nangaku, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka, In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancer. Nat. Commun. 10 1894 (2019) (DOI: 10.1038/s41467-019-09856-w)
  5. T. Takai, T. Tsujino, Y. Yoshikawa, T. Inamoto, N. Sugito, Y. Kuranaga, T. Soga, K. Hayashi, K. Miyata, K. Kataoka, H. Azuma, Y. Akao, Synthetic miR-143 exhibited an anti-cancer effect via downregulation of K-RAS networks of renal cell cancer cells in vitro and in vivo. Mol. Ther. 27 (5) 1-11 (2019) (DOI: 10.1016/j.ymthe.2019.03.004)
  6. Y. Yoshikawa, K. Taniguchi, T. Tsujino, K. Heishima, T. Inamoto, T. Takai, K. Minami, H. Azuma, K. Miyata, K. Hayashi, K. Kataoka, Y. Akao, Anti-cancer effects of a chemically modified miR-143 on bladder cancer by either systemic or intravesical treatment. Mol. Ther. Methods Clin. Dev. 13 290-302 (2019) (DOI: 10.1016/j.omtm.2019.02.005)
  7. B. S. Kim, S. Chuanoi, T. Suma, Y. Anraku, K. Hayashi, M. Naito, H. J. Kim, I. C. Kwon, K. Miyata, A. Kishimura, K. Kataoka, Self-assembly of siRNA/PEG-b-catiomer at integer molar ratio into 100 nm-sized vesicular polyion complexes (siRNAsomes) for RNAi and codelivery of cargo macromolecules. J. Am. Chem. Soc. 141 (8) 3699-3709 (2019) (DOI: 10.1021/jacs.8b13641)
  8. M. Naito, Y. Otsu, R. Kamegawa, K. Hayashi, S. Uchida, H. J. Kim, K. Miyata, Tunable non-enzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency. Sci. Technol. Adv. Mater. 20 (1) 105-115 (2019) (DOI: 10.1080/14686996.2019.1569818)
  9. Y. Yi, H. J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka, Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J. Control. Release 295 268-277 (2019) (DOI: 10.1016/j.jconrel.2019.01.006)
  10. H. S. Min, H. J. Kim, J. Y. Ahn, M. Naito, K. Hayashi, K. Toh, B. S. Kim, Y. Matsumura, I. C. Kwon, K. Miyata, K. Kataoka, Tuned density of anti-tissue factor antibody fragment onto siRNA-loaded polyion complex micelle for optimizing targetability into pancreatic cancer cells. Biomacromolecules 19 (6) 2320-2329 (2018) (DOI: 10.1021/acs.biomac.8b00507)
  11. M. Naito, N. Yoshinaga, T. Ishii, A. Matsumoto, Y. Miyahara, K. Miyata, K. Kataoka, Enhanced intracellular delivery of siRNA by controlling ATP-responsivity of phenylboronic acid-functionalized polyion complex micelles. Macromol. Biosci. 18 (1) 1700357 (2018) (DOI: 10.1002/mabi.201700357)
  12. Y. Zou, M. Zheng, W. Yang, F. Meng, K. Miyata, H. J. Kim, K. Kataoka, Z. Zhong, Virus-mimicking chimaeric polymersomes boost targeted cancer siRNA therapy in vivo. Adv. Mater. 29 Issue42 1703285 (2017) (DOI: 10.1002/adma.201703285)
  13. Y. Anraku, H. Kuwahara, Y. Fukusato, A. Mizoguchi, T. Ishii, K. Nitta, Y. Matsumoto, K. Toh, K. Miyata, S. Uchida, K. Nishina, K. Osada, K. Itaka, N. Nishiyama, H. Mizusawa, T. Yamasoba, T. Yokota, K. Kataoka, Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nat. Commun. 8 1001 (2017) (DOI: 10.1038/s41467-017-00952-3)
  14. K. Klinker, O. Schäfer, D. Huesmann, T. Bauer, L. Capelôa, L. Braun, N. Stergiou, M. Schinnerer, A. Dirisala, K. Miyata, K. Osada, H. Cabral, K. Kataoka, M. Barz, Secondary structure-driven self-assembly of reactive polypept(o)ides: Controlling size, shape and function of core cross-linked nanostructures. Angew. Chem. Int. Ed. 56 (32) 9608-9613 (2017) (DOI: 10.1002/anie.201702624)
  15. M. Naito, R. Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H. J. Kim, T. Ishii, N. Nishiyama, K. Miyata, K. Kataoka, Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery. J. Biomater. Sci. Polym. Ed. 28 Issue10-12 1109-1123 (2017) (DOI: 10.1080/09205063.2017.1301775)
  16. C. Moriya, H. Taniguchi, K. Miyata, N. Nishiyama, K. Kataoka, K. Imai, Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice. Carcinogenesis 38 (6) 638-648 (2017) (DOI: 10.1093/carcin/bgx040)
  17. Y. Yi, H. J. Kim, P. Mi, M. Zheng, H. Takemoto, K. Toh, B. S. Kim, K. Hayashi, M. Naito, Y. Matsumoto, K. Miyata, K. Kataoka, Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles. J. Control. Release 244 PartB 247-256 (2016) (DOI: 10.1016/j.jconrel.2016.08.041)
    The 14th edition of the European Symposium on Controlled Drug Delivery, Egmond aan Zee, The Netherlands on April 13-15, 2016
  18. K. Katsushima, A. Natsume, F. Ohta, K. Shinjo, A. Hatanaka, N. Ichimura, S. Sato, S. Takahashi, H. Kimura, Y. Totoki, T. Shibata, M. Naito, H. J. Kim, K. Miyata, K. Kataoka, Y. Kondo, Targeting the notch-regulated non-coding RNA TUG1 for glioma treatment. Nat. Commun. 7 13616 (2016) (DOI: 10.1038/ncomms13616)
  19. H. Nishida, Y. Matsumoto, K. Kawana, R. J. Christie, M. Naito, B. S. Kim, K. Toh, H. S. Min, Y. Yi, Y. Matsumoto, H. J. Kim, K. Miyata, A. Taguchi, K. Tomio, A. Yamashita, T. Inoue, H. Nakamura, A. Fujimoto, M. Sato, M. Yoshida, K. Adachi, T. Arimoto, O. Wada-Hiraike, K. Oda, T. Nagamatsu, N. Nishiyama, K. Kataoka, Y. Osuga, T. Fujii, Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes. J. Control. Release 231 29-37 (2016) (DOI: 10.1016/j.jconrel.2016.03.016)
  20. F. Perche, Y. Yi, L. Hespel, P. Mi, A. Dirisala, H. Cabral, K. Miyata, K. Kataoka, Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity. Biomaterials 90 62-71 (2016) (DOI: 10.1016/j.biomaterials.2016.02.027)
  21. K. Hayashi, H. Chaya, S. Fukushima, S. Watanabe, H. Takemoto, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka, Influence of RNA strand rigidity on polyion complex formation with block catiomers. Macromol. Rapid Commun. 37 (6) 486-493 (2016) (DOI: 10.1002/marc.201500661)
  22. H. Uchida, K. Itaka, S. Uchida, T. Ishii, T. Suma, K. Miyata, M. Oba, N. Nishiyama, K. Kataoka, Synthetic polyamines to regulate mRNA translation through the preservative binding of eukaryotic initiation factor 4E to the cap structure. J. Am. Chem. Soc. 138 (5) 1478-1481 (2016) (DOI: 10.1021/jacs.5b11726)
  23. T. Ishii, K. Miyata, Y. Anraku, M. Naito, Y. Yi, T. Jinbo, S. Takae, Y. Fukusato, M. Hori, K. Osada, K. Kataoka, Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths. Chem. Commun. 52 (7) 1517-1519 (2016) (DOI: 10.1039/C5CC06661A)
  24. M. Tangsangasaksri, H. Takemoto, M. Naito, Y. Maeda, D. Sueyoshi, H. J. Kim, Y. Miura, J. Y. Ahn, R. Azuma, N. Nishiyama, K. Miyata, K. Kataoka, siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting enhanced RNAi efficacy. Biomacromolecules 17 (1) 246-255 (2016) (DOI: 10.1021/acs.biomac.5b01334)
  25. Y. Nomura, M. Kaneko, K. Miyata, Y. Yatomi, Y. Yanagi, Bevacizumab and aflibercept activate platets via Fc RIIa. Invest. Ophthal. Vis. Sci. 56 (13) 8075-8082 (2015) (DOI: 10.1167/iovs.15-17814)
  26. M. Murakami, K. Nishina, C. Watanabe, K. Y. Tanaka, W. Piao, H. Kuwahara, Y. Horikiri, K. Miyata, N. Nishiyama, K. Kataoka, M. Yoshida, H. Mizusawa, T. Yokota, Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route. Sci. Rep. 5 17035 (2015) (DOI: 10.1038/srep17035)
  27. K. Nishina, W. Piao, K. Y-Tanaka, Y. Sujino, T. Nishina, T. Yamamoto, K. Nitta, K. Yoshioka, H. Kuwahara, H. Yasuhara, T. Baba, F. Ono, K. Miyata, K. Miyake, P. P. Seth, A. Low, M. Yoshida, C. F. Bennett, K. Kataoka, H. Mizusawa, S. Obika, T. Yokota, DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. Nat. Commun. 6 7969 (2015) (DOI: 10.1038/ncomms8969)
  28. H. Ogawa, X. Wu, K. Kawamoto, N. Nishida, M. Konno, J. Koseki, H. Matsui, K. Noguchi, N. Gotoh, T. Yamamoto, K. Miyata, N. Nishiyama, H. Nagano, H. Yamamoto, S. Obika, K. Kataoka, Y. Doki, M. Mori, H. Ishii, MicroRNAs induce epigenetic reprogramming and suppress malignant phenotypes of human colon cancer cells. PLOS ONE 10(5) e0127119 (2015) (DOI: 10.1371/journal.pone.0127119)
  29. H. Gao, H. Takemoto, Q. Chen, M. Naito, H. Uchida, X. Liu, K. Miyata, K. Kataoka, Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity. Chem. Commun. 51 (15) 3158-3161 (2015) (DOI: 10.1039/C4CC09859E)
  30. L. Nuhn, S. Tomcin, K. Miyata, V. Mailander, K. Landfester, K. Kataoka, R. Zentel, Size-dependent knockdown potential of siRNA-loaded cationic nanohydrogel particles. Biomacromolecules 15 (11) 4111-4121 (2014) (DOI: 10.1021/bm501148y)
  31. H. J. Kim, H. Takemoto, Y. Yi, M. Zheng, Y. Maeda, H. Chaya, K. Hayashi, P. Mi, F. Pittella, R. J. Christie, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka, Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles. ACS Nano 8 (9) 8979-8991 (2014) (DOI: 10.1021/nn502125h)
  32. H. Uchida, K. Itaka, T. Nomoto, T. ishii, T. Suma, M. Ikegami, K. Miyata, M. Oba, N. Nishiyama, K. Kataoka, Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection. J. Am. Chem. Soc. 136 (35) 12396-12405 (2014) (DOI: 10.1021/ja506194z) Selected as Spotlights of JACS
  33. Y. Oe, R. J. Christie, M. Naito, S. A. Low, S. Fukushima, K. Toh, Y. Miura, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka, Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors. Biomaterials 35 27 7887-7895 (2014) (DOI: 10.1016/j.biomaterials.2014.05.041)
  34. Y. Maeda, F. Pittella, T. Nomoto, H. Takemoto, N. Nishiyama, K. Miyata, K. Kataoka, Fine-tuning of charge-conversion polymer structure for efficient endosomal escape of siRNA-loaded calcium phosphate hybrid micelles. Macromol. Rapid Commun. 35 (13) 1211-1215 (2014) (DOI: 10.1002/marc.201400049)
  35. A. Dirisala, K. Osada, Q. Chen, T. A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka, K. Kataoka, Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials 35 (20) 5359-5368 (2014) (DOI: 10.1016/j.biomaterials.2014.03.037)
  36. L. Nuhn, S. Gietzen, K. Mohr, K. Fischer, K. Toh, K. Miyata, Y. Matsumoto, K. Kataoka, M. Schmidt, R. Zentel, Aggregation behavior of cationic nanohydrogel particles in human blood serum. Biomacromolecules 15 (4) 1526-1533 (2014) (DOI: 10.1021/bm500199h)
  37. S. Murayama, P. Kos, K. Miyata, K. Kataoka, E. Wagner, M. Kato, Gene regulation by intracellular delivery and photodegradation of nanoparticles containing small interfering RNA. Macromol. Biosci. 14 (5) 626-631 (2014) (DOI: 10.1002/mabi.201300393)
  38. H. J. Kim, K. Miyata, T. Nomoto, M. Zheng, A. Kim, X. Liu, H. Cabral, R. J. Christie, N. Nishiyama, K. Kataoka, siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials 35 (15) 4548-4556 (2014) (DOI: 10.1016/j.biomaterials.2014.02.016)
  39. T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, Arnida, Y. Matsumoto, M. Oba, K. Miyata, K. Osada, N. Nishiyama, K. Kataoka, Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer. Nat. Commun. 5 3545 (2014) (DOI: 10.1038/ncomms4545)
  40. F. Pittella, H. Cabral, Y. Maeda, P. Mi, S. Watanabe, H. Takemoto, H. J. Kim, N. Nishiyama, K. Miyata, K. Kataoka, Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles. J. Control. Release 178 18-24 (2014) (DOI: 10.1016/j.jconrel.2014.01.008)
  41. H. J. Kim, T. Ishii, M. Zheng, S. Watanabe, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka, Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer. Drug Deliv. Transl. Res. 4 (1) 50-60 (2014) (DOI: 10.1007/s13346-013-0175-6)
  42. S. Biswas, K. Kinbara, T. Niwa, H. Taguchi, N. Ishii, S. Watanabe, K. Miyata, K. Kataoka, T. Aida, Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP. Nat. Chem. 5 613-620 (2013) (DOI: 10.1038/NCHEM.1681)
  43. H. Takemoto, K. Miyata, S. Hattori, T. Ishii, T. Suma, S. Uchida, N. Nishiyama, K. Kataoka, Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response. Angew. Chem. Int. Ed. 52 (24) 6218-6221 (2013) (DOI: 10.1002/anie.201300178)
  44. S. Wu, V. Kasim, M. R. Kano, S. Tanaka, S. Ohba, Y. Miura, K. Miyata, X. Liu, A. Matsuhashi, U. -l. Chung, K. Kataoka, N. Nishiyama, M. Miyagishi, Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner. Cancer Res. 73 (6) 1787-1799 (2013) (DOI: 10.1158/0008-5472.CAN-12-0366)
  45. N. Gouda, K. Miyata, R. J. Christie, T. Suma, A. Kishimura, S. Fukushima, T. Nomoto, X. Liu, N. Nishiyama, K. Kataoka, Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA. Biomaterials 34 (2) 562-570 (2013) (DOI: 10.1016/j.biomaterials.2012.09.077)
  46. M. Naito, T. Ishii, A. Matsumoto, K. Miyata, Y. Miyahara, K. Kataoka, A phenylboronate-functionalized polyion complex micelle for ATP-triggered release of siRNA. Angew. Chem. Int. Ed. 51 (43) 10751-10755 (2012) (DOI: 10.1002/anie.201203360)
  47. M. Sanjoh, K. Miyata, R. J. Christie, T. Ishii, Y. Maeda, F. Pittella, S. Hiki, N. Nishiyama, K. Kataoka, Dual environment-responsive polyplex carriers for enhanced intracellular delivery of plasmid DNA. Biomacromolecules 13 (11) 3641-3649 (2012) (DOI: 10.1021/bm301095a)
  48. T. Suma, K. Miyata, Y. Anraku, S. Watanabe, R. J. Christie, H. Takemoto, M. Shioyama, N. Gouda, T. Ishii, N. Nishiyama, K. Kataoka, Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG. ACS Nano 6 (8) 6693-6705 (2012) (DOI: 10.1021/nn301164a)
  49. F. Pittella, K. Miyata, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R. J. Christie, K. Osada, N. Nishiyama, K. Kataoka, Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles. J. Control. Release 161 (3) 868-874 (2012) (DOI: 10.1016/j.jconrel.2012.05.005)
  50. H. Takemoto, K. Miyata, T. Ishii, S. Hattori, S. Osawa, N. Nishiyama, K. Kataoka, Accelerated polymer-polymer click conjugation by freeze-thaw treatment. Bioconjugate Chem. 23 (8) 1503-1506 (2012) (DOI: 10.1021/bc300182y)
  51. R. J. Christie, Y. Matsumoto, K. Miyata, T. Nomoto, S. Fukushima, K. Osada, J. Halnaut, F. Pittella, H. J. Kim, N. Nishiyama, K. Kataoka, Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection. ACS Nano 6 (6) 5174-5189 (2012) (DOI: 10.1021/nn300942b)
  52. T. Suma, K. Miyata, T. Ishii, S. Uchida, H. Uchida, K. Itaka, N. Nishiyama, K. Kataoka, Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain. Biomaterials 33 (9) 2770-2779 (2012) (DOI: 10.1016/j.biomaterials.2011.12.022)
  53. H. J. Kim, M. Oba, F. Pittella, T. Nomoto, H. Cabral, Y. Matsumoto, K. Miyata, N. Nishiyama, K. Kataoka, PEG-detachable cationic polyaspartamide derivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor. J. Drug Target. 20 (1) 33-42 (2012) (DOI: 10.3109/1061186X.2011.632010)
  54. F. M. Mickler, Y. Vachutinsky, M. Oba, K. Miyata, N. Nishiyama, K. Kataoka, C. Brachle, N. Ruthardt, Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging. J. Control. Release 156 (3) 364-373 (2011) (DOI: 10.1016/j.jconrel.2011.08.003)
  55. A. Iriyama, T. Usui Y. Yanagi, S. Amano M. Oba, K. Miyata, N. Nishiyama, K. Kataoka, Gene transfer using micellar nanovectors inhibits corneal neovascularization in vivo. Cornea 30 (12) 1423-1427 (2011) (DOI: 10.1097/ICO.0b013e318206c893)
  56. S. Uchida, K. Itaka, Q. Chen, K. Osada, K. Miyata, T. Ishii, M. Harada-Shiba, K. Kataoka, Combination of chondroitin sulfate and polyplex micelles from poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity. J. Control. Release 155 (2) 296-302 (2011) (DOI: 10.1016/ j.jconrel.2011.04.026)
  57. H. Uchida, K. Miyata, M. Oba, T. Ishii, T. Suma, K. Itaka, N. Nishiyama, K. Kataoka, Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles. J. Am. Chem. Soc. 133 (39) 15524-15532 (2011) (DOI: 10.1021/ja204466y)
  58. R. J. Christie, K. Miyata, Y. Matsumoto, T. Nomoto, D. Menasco, T. -C. Lai, M. Pennisi, K. Osada, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka, Effect of polymer structure on micelles formed between siRNA and cationic block copolymer comprising thiols and amidines. Biomacromolecules 12 (9) 3174-3185 (2011) (DOI: 10.1021/bm2006714)
  59. Y. Uno, W. Piao, K. Miyata, K. Nishina, H. Mizusawa, T. Yokota, HDL facilitates in vivo delivery of a-tocopherol-conjugated siRNA to the brain. Hum. Gene Ther. 22 (6) 711-719 (2011) (DOI: 10.1089/hum.2010.083.)
  60. T. Nomoto, Y. Matsumoto, K. Miyata, M. Oba, S. Fukushima, N. Nishiyama, T. Yamasoba, K. Kataoka, In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy. J. Control. Release 151 (2) 104-109 (2011) (DOI: 10.1016/j.jconrel.2011.02.011)
  61. F. Pittella, M. Zhang, Y. Lee, H. J. Kim, T. Tockary, K. Osada, T. Ishii, K. Miyata, N. Nishiyama, K. Kataoka, Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity. Biomaterials 32 (11) 3106-3114 (2011) (DOI: 10.1016/j.biomaterials.2010.12.057)
  62. M. Oba, K. Miyata, K. Osada, R. J. Christie, M. Sanjoh, W. Li, S. Fukushima, T. Ishii, M. R. Kano, N. Nishiyama, H. Koyama, K. Kataoka, Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery. Biomaterials 32 (2) 652-663 (2011) (DOI: 10.1016/j.biomaterials.2010.09.022)
  63. Y. Vachutinsky, M. Oba, K. Miyata, S. Hiki, M. R. Kano, N. Nishiyama, H. Koyama, K. Miyazono, K. Kataoka, Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles. J. Control. Release 149 (1) 51-57 (2011) (DOI: 10.1016/j.jconrel.2010.02.002)
  64. H. Takemoto, A. Ishii, K. Miyata, M. Nakanishi, M. Oba, T. Ishii, Y. Yamasaki, N. Nishiyama, K. Kataoka, Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system. Biomaterials 31 (31) 8097-8105 (2010) (DOI: 10.1016/j.biomaterials. 2010.07.015)
  65. Y. Matsumoto, T. Nomoto, H. Cabral, Y. Matsumoto, S. Watanabe, R. J. Christie, K. Miyata, M. Oba, T. Ogura, Y. Yamasaki, N. Nishiyama, T. Yamasoba, K. Kataoka, Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography. Biomed. Opt. Express 1 (4) 1209-1216 (2010) (DOI: 10.1364/BOE. 1.001209)
  66. H. J. Kim, A. Ishii, K. Miyata, Y. Lee, S. Wu, M. Oba, N. Nishiyama, K. Kataoka, Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown. J. Control. Release 145 (2) 141-148 (2010) (DOI: 10.1016/j.jconrel.2010.03.019)
  67. M. Sanjoh, S. Hiki, Y. Lee, M. Oba, K. Miyata, T. Ishii, K. Kataoka, pDNA/poly(L-lysine) polyplexes functionalized with a pH-Sensitive charge-conversional poly(aspartamide) derivative for controlled gene delivery to human umbilical vein endothelial cells. Macromol. Rapid Commun. 31 (13) 1181-1186 (2010) (DOI: 10.1002/marc.201000056)
  68. K. Miyata, N. Gouda, H. Takemoto, M. Oba, Y. Lee, H. Koyama, Y. Yamasaki, K. Itaka, N. Nishiyama, K. Kataoka, Enhanced transfection with silica-coated polyplexes loading plasmid DNA. Biomaterials 31 (17) 4764-4770 (2010) (DOI: 10.1016/j.biomaterials.2010.02.033)
  69. M. Oba, Y. Vachutinsky, K. Miyata, M. R. Kano, S. Ikeda, N. Nishiyama, K. Itaka, K. Miyazono, H. Koyama, K. Kataoka, Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1. Mol. Pharmaceut. 7 (2) 501-509 (2010) (DOI: 10.1021/mp9002317)
  70. H. Shimizu, Y. Hori, S. Kaname, K. Yamada, N. Nishiyama, S. Matsumoto, K. Miyata, M. Oba, A. Yamada, K. Kataoka, T. Fujita, siRNA-based therapy ameliorates glomerulonephritis. J. Am. Soc. Nephrol. 21 (4) 622-633 (2010) (DOI: 10.1681/ASN.2009030295)
  71. M. Harada-Shiba, I. Takamisawa, K. Miyata, T. Ishii, N. Nishiyama, K. Itaka, K. Kangawa, F. Yoshihara, Y. Asada, K. Hatakeyama, N. Nagaya, K. Kataoka, Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats. Mol. Ther. 17 (7) 1180-1186 (2009) (DOI: 10.1038/mt.2009.63)
  72. S. Matsumoto, R. J. Christie, N. Nishiyama, K. Miyata, A. Ishii, M. Oba, H. Koyama, Y. Yamasaki, K. Kataoka, Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery. Biomacromolecules 10 (1) 119-127 (2009) (DOI: 10.1021/bm800985e)
  73. K. Miyata, M. Oba, M. Nakanishi, S. Fukushima, Y. Yamasaki, H. Koyama, N. Nishiyama, K. Kataoka, Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity. J. Am. Chem. Soc. 130 (48) 16287-16294 (2008) (DOI: 10.1021/ja804561g)
  74. K. Miyata, M. Oba, M. R. Kano, S. Fukushima, Y. Vachutinsky, M. Han, H. Koyama, K. Miyazono, N. Nishiyama, K. Kataoka, Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor. Pharm. Res. 25 (12) 2924-2936 (2008) (DOI: 10.1007/s11095-008-9720-2)
  75. M. Oba, K. Aoyagi, K. Miyata, Y. Matsumoto, K. Itaka, N. Nishiyama, Y. Yamasaki, H. Koyama, K. Kataoka, Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking. Mol. Pharmaceut. 5 (6) 1080-1092 (2008) (DOI: 10.1021/mp800070s)
  76. Y. Lee, K. Miyata, M. Oba, T. Ishii, S. Fukushima, M. Han, H. Koyama, N. Nishiyama, K. Kataoka, Charge-conversion ternary polyplex with endosome disruption moiety: A technique for efficient and safe gene delivery. Angew. Chem. Int. Ed. 47 (28) 5163-5166 (2008) (DOI: 10.1002/anie.200800963)
  77. S. Takae, K. Miyata, M. Oba, T. Ishii, N. Nishiyama, K. Itaka, Y. Yamasaki, H. Koyama, K. Kataoka, PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors. J. Am. Chem. Soc. 130 (18) 6001-6009 (2008) (DOI: 10.1021/ja800336v)
  78. K. Miyata, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka, PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy. J. Control. Release 122 (3) 252-260 (2007) (DOI: 10.1016/j.jconrel.2007.06.020)
  79. K. Itaka, S. Ohba, K. Miyata, H. Kawaguchi, K. Nakamura, T. Takato, U. -I. Chung, K. Kataoka, Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol. Ther. 15 (9) 1655-1662 (2007) (DOI: 10.1038/
  80. M. Han, Y. Bae, N. Nishiyama, K. Miyata, M. Oba, K. Kataoka, Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies. J. Control. Release 121 (1-2) 38-48 (2007) (DOI: 10.1016/j.jconrel.2007.05.012)
  81. N. Nishiyama, Arnida, W. -D. Jang, K. Date, K. Miyata, K. Kataoka, Photochemical enhancement of transgene expression by polymeric micelles incorporating plasmid DNA and dendrimer-based photosensitizer. J. Drug Target. 14 (6) 413-424 (2006) (DOI: 10.1080/10611860600834508)
  82. N. Kanayama, S. Fukushima, N. Nishiyama, K. Itaka, W. -D. Jang, K. Miyata, Y. Yamasaki, U. -I. Chung, K. Kataoka, A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells. ChemMedChem. 1 (4) 439-444 (2006) (DOI: 10.1002/cmdc.200600008)
  83. K. Miyata, Y. Kakizawa, N. Nishiyama, Y. Yamasaki, T. Watanabe, M. Kohara, K. Kataoka, Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelles with disulfide crosslinked cores to the liver. J. Control. Release 109 (1-3) 15-23 (2005) (DOI: 10.1016/j.jconrel.2005.09.043)
  84. N. Nishiyama, A. Iriyama, W. -D. Jang, K. Miyata, K. Itaka, Y. Inoue, H. Takahashi, Y. Yanagi, Y. Tamaki, H. Koyama, K. Kataoka, Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer. Nat. Mater. 4 (12) 934-941 (2005) (DOI: 10.1038/nmat1524)
  85. S. Fukushima, K. Miyata, N. Nishiyama, N. Kanayama, Y. Yamasaki, K. Kataoka, PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery. J. Am. Chem. Soc. 127 (9) 2810-2811 (2005) (DOI: 10.1021/ja0440506)
  86. D. Wakebayashi, N. Nishiyama, K. Itaka, K. Miyata, Y. Yamasaki, A. Harada, H. Koyama, Y. Nagasaki, K. Kataoka, Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficacy. Biomacromolecules 5 (6) 2128-2136 (2004) (DOI: 10.1021/bm040009j)
  87. Y. Kakizawa, K. Miyata, S. Furukawa, K. Kataoka, Size-controlled formation of a calcium phosphate-based organic-inorganic hybrid vector for gene delivery using poly(ethylene glycol)-block-poly(aspartic acid). Adv. Mater. 16 (8) 699-702 (2004) (DOI: 10.1002/adma.200305782)
  88. K. Miyata, Y. Kakizawa, N. Nishiyama, A. Harada, Y. Yamasaki, H. Koyama, K. Kataoka, Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. J. Am. Chem. Soc. 126 (8) 2355-2361 (2004) (DOI: 10.1021/ja0379666)
Miyata laboratory
The University of Tokyo, Department of Materials Engineering, Bld.#4, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656