Aug. 6 2019 Updated


  1. B. -S. Kim, H. -J. Kim, S. Osawa, K. Hayashi, K. Toh, M. Naito, H. S. Min, Y. Yi, I. -C. Kwon, K. Kataoka, K. Miyata, Dually stabilized triblock copolymer micelles with hydrophilic shell and hydrophobic interlayer for systemic antisense oligonucleotide delivery to solid tumor. ACS Biomater. Sci. Eng. in press.
  2. S. Watanabe, K. Hayashi, K. Toh, H. J. Kim, X. Liu, H. Chaya, S. Fukushima, K. Katsushima, Y. Kondo, S. Uchida, S. Ogura, T. Nomoto, H. Takemoto, H. Cabral, H. Kinoh, H. Tanaka, M. R. Kano, Y. Matsumoto, H. Fukuhara, S. Uchida, M. Nangaku, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka, In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancer. Nat. Commun. 10 1894 (2019) (DOI: 10.1038/s41467-019-09856-w)
  3. T. Takai, T. Tsujino, Y. Yoshikawa, T. Inamoto, N. Sugito, Y. Kuranaga, T. Soga, K. Hayashi, K. Miyata, K. Kataoka, H. Azuma, Y. Akao, Synthetic miR-143 exhibited an anti-cancer effect via downregulation of K-RAS networks of renal cell cancer cells in vitro and in vivo. Mol. Ther. 27 (5) 1-11 (2019) (DOI: 10.1016/j.ymthe.2019.03.004)
  4. Y. Yoshikawa, K. Taniguchi, T. Tsujino, K. Heishima, T. Inamoto, T. Takai, K. Minami, H. Azuma, K. Miyata, K. Hayashi, K. Kataoka, Y. Akao, Anti-cancer effects of a chemically modified miR-143 on bladder cancer by either systemic or intravesical treatment. Mol. Ther. Methods Clin. Dev. 13 290-302 (2019) (DOI: 10.1016/j.omtm.2019.02.005)
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  6. M. Naito, Y. Otsu, R. Kamegawa, K. Hayashi, S. Uchida, H. -J. Kim, K. Miyata, Tunable non-enzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency. Sci. Technol. Adv. Mater. 20 (1) 105-115 (2019) (DOI: 10.1080/14686996.2019.1569818)
  7. Y. Yi, H. J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka, Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J. Control. Release 295 268-277 (2019) (DOI: 10.1016/j.jconrel.2019.01.006)
  8. H. -S. Min, H. -J. Kim, J. -Y. Ahn, M. Naito, K. Hayashi, K. Toh, B. -S. Kim, Y. Matsumura, I.-C. Kwon, K. Miyata, K. Kataoka, Tuned density of anti-tissue factor antibody fragment onto siRNA-loaded polyion complex micelle for optimizing targetability into pancreatic cancer cells. Biomacromolecules 19 (6) 2320-2329 (2018) (DOI: 10.1021/acs.biomac.8b00507)
  9. M. Naito, N. Yoshinaga, T. Ishii, A. Matsumoto, Y. Miyahara, K. Miyata, K. Kataoka, Enhanced intracellular delivery of siRNA by controlling ATP-responsivity of phenylboronic acid-functionalized polyion complex micelles. Macromol. Biosci. 18 (1) 1700357 (2018) (DOI: 10.1002/mabi.201700357)
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  12. K. Klinker, O. Schäfer, D. Huesmann, T. Bauer, L. Capelôa, L. Braun, N. Stergiou, M. Schinnerer, A. Dirisala, K. Miyata, K. Osada, H. Cabral, K. Kataoka, M. Barz, Secondary structure-driven self-assembly of reactive polypept(o)ides: Controlling size, shape and function of core cross-linked nanostructures. Angew. Chem. Int. Ed. 56 (32) 9608-9613 (2017) (DOI: 10.1002/anie.201702624)
  13. M. Naito, R. Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H. -J. Kim, T. Ishii, N. Nishiyama, K. Miyata, K. Kataoka, Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery. J. Biomater. Sci. Polym. Ed. 28 Issue10-12 1109-1123 (2017) (DOI: 10.1080/09205063.2017.1301775)
  14. C. Moriya, H. Taniguchi, K. Miyata, N. Nishiyama, K. Kataoka, K. Imai, Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice. Carcinogenesis 38 (6) 638-648 (2017) (DOI: 10.1093/carcin/bgx040)
  15. Y. Yi, H. -J. Kim, P. Mi, M. Zheng, H. Takemoto, K. Toh, B. -S. Kim, K. Hayashi, M. Naito, Y. Matsumoto, K. Miyata, K. Kataoka, Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles. J. Control. Release 244 PartB 247-256 (2016) (DOI: 10.1016/j.jconrel.2016.08.041)
    The 14th edition of the European Symposium on Controlled Drug Delivery, Egmond aan Zee, The Netherlands on April 13-15, 2016
  16. K. Katsushima, A. Natsume, F. Ohta, K. Shinjo, A. Hatanaka, N. Ichimura, S. Sato, S. Takahashi, H. Kimura, Y. Totoki, T. Shibata, M. Naito, H. -J. Kim, K. Miyata, K. Kataoka, Y. Kondo, Targeting the notch-regulated non-coding RNA TUG1 for glioma treatment. Nat. Commun. 7 13616 (2016) (DOI: 10.1038/ncomms13616)
  17. H. Nishida, Y. Matsumoto, K. Kawana, R. J. Christie, M. Naito, B. -S. Kim, K. Toh, H. -S. Min, Y. Yi, Y. Matsumoto, H. -J. Kim, K. Miyata, A. Taguchi, K. Tomio, A. Yamashita, T. Inoue, H. Nakamura, A. Fujimoto, M. Sato, M. Yoshida, K. Adachi, T. Arimoto, O. Wada-Hiraike, K. Oda, T. Nagamatsu, N. Nishiyama, K. Kataoka, Y. Osuga, T. Fujii, Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes. J. Control. Release 231 29-37 (2016) (DOI: 10.1016/j.jconrel.2016.03.016)
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  22. M. Tangsangasaksri, H. Takemoto, M. Naito, Y. Maeda, D. Sueyoshi, H. -J. Kim, Y. Miura, J. -Y. Ahn, R. Azuma, N. Nishiyama, K. Miyata, K. Kataoka, siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting enhanced RNAi efficacy. Biomacromolecules 17 (1) 246-255 (2016) (DOI: 10.1021/acs.biomac.5b01334)
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  65. M. Sanjoh, S. Hiki, Y. Lee, M. Oba, K. Miyata, T. Ishii, K. Kataoka, pDNA/poly(L-lysine) polyplexes functionalized with a pH-Sensitive charge-conversional poly(aspartamide) derivative for controlled gene delivery to human umbilical vein endothelial cells. Macromol. Rapid Commun. 31 (13) 1181-1186 (2010) (DOI: 10.1002/marc.201000056)
  66. K. Miyata, N. Gouda, H. Takemoto, M. Oba, Y. Lee, H. Koyama, Y. Yamasaki, K. Itaka, N. Nishiyama, K. Kataoka, Enhanced transfection with silica-coated polyplexes loading plasmid DNA. Biomaterials 31 (17) 4764-4770 (2010) (DOI: 10.1016/j.biomaterials.2010.02.033)
  67. M. Oba, Y. Vachutinsky, K. Miyata, M. R. Kano, S. Ikeda, N. Nishiyama, K. Itaka, K. Miyazono, H. Koyama, K. Kataoka, Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1. Mol. Pharmaceut. 7 (2) 501-509 (2010) (DOI: 10.1021/mp9002317)
  68. H. Shimizu, Y. Hori, S. Kaname, K. Yamada, N. Nishiyama, S. Matsumoto, K. Miyata, M. Oba, A. Yamada, K. Kataoka, T. Fujita, siRNA-based therapy ameliorates glomerulonephritis. J. Am. Soc. Nephrol. 21 (4) 622-633 (2010) (DOI: 10.1681/ASN.2009030295)
  69. M. Harada-Shiba, I. Takamisawa, K. Miyata, T. Ishii, N. Nishiyama, K. Itaka, K. Kangawa, F. Yoshihara, Y. Asada, K. Hatakeyama, N. Nagaya, K. Kataoka, Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats. Mol. Ther. 17 (7) 1180-1186 (2009) (DOI: 10.1038/mt.2009.63)
  70. S. Matsumoto, R. J. Christie, N. Nishiyama, K. Miyata, A. Ishii, M. Oba, H. Koyama, Y. Yamasaki, K. Kataoka, Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery. Biomacromolecules 10 (1) 119-127 (2009) (DOI: 10.1021/bm800985e)
  71. K. Miyata, M. Oba, M. Nakanishi, S. Fukushima, Y. Yamasaki, H. Koyama, N. Nishiyama, K. Kataoka, Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity. J. Am. Chem. Soc. 130 (48) 16287-16294 (2008) (DOI: 10.1021/ja804561g)
  72. K. Miyata, M. Oba, M. R. Kano, S. Fukushima, Y. Vachutinsky, M. Han, H. Koyama, K. Miyazono, N. Nishiyama, K. Kataoka, Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor. Pharm. Res. 25 (12) 2924-2936 (2008) (DOI: 10.1007/s11095-008-9720-2)
  73. M. Oba, K. Aoyagi, K. Miyata, Y. Matsumoto, K. Itaka, N. Nishiyama, Y. Yamasaki, H. Koyama, K. Kataoka, Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking. Mol. Pharmaceut. 5 (6) 1080-1092 (2008) (DOI: 10.1021/mp800070s)
  74. Y. Lee, K. Miyata, M. Oba, T. Ishii, S. Fukushima, M. Han, H. Koyama, N. Nishiyama, K. Kataoka, Charge-conversion ternary polyplex with endosome disruption moiety: A technique for efficient and safe gene delivery. Angew. Chem. Int. Ed. 47 (28) 5163-5166 (2008) (DOI: 10.1002/anie.200800963)
  75. S. Takae, K. Miyata, M. Oba, T. Ishii, N. Nishiyama, K. Itaka, Y. Yamasaki, H. Koyama, K. Kataoka, PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors. J. Am. Chem. Soc. 130 (18) 6001-6009 (2008) (DOI: 10.1021/ja800336v)
  76. K. Miyata, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka, PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy. J. Control. Release 122 (3) 252-260 (2007) (DOI: 10.1016/j.jconrel.2007.06.020)
  77. K. Itaka, S. Ohba, K. Miyata, H. Kawaguchi, K. Nakamura, T. Takato, U. -I. Chung, K. Kataoka, Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol. Ther. 15 (9) 1655-1662 (2007) (DOI: 10.1038/
  78. M. Han, Y. Bae, N. Nishiyama, K. Miyata, M. Oba, K. Kataoka, Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies. J. Control. Release 121 (1-2) 38-48 (2007) (DOI: 10.1016/j.jconrel.2007.05.012)
  79. N. Nishiyama, Arnida, W. -D. Jang, K. Date, K. Miyata, K. Kataoka, Photochemical enhancement of transgene expression by polymeric micelles incorporating plasmid DNA and dendrimer-based photosensitizer. J. Drug Target. 14 (6) 413-424 (2006) (DOI: 10.1080/10611860600834508)
  80. N. Kanayama, S. Fukushima, N. Nishiyama, K. Itaka, W. -D. Jang, K. Miyata, Y. Yamasaki, U. -I. Chung, K. Kataoka, A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells. ChemMedChem. 1 (4) 439-444 (2006) (DOI: 10.1002/cmdc.200600008)
  81. K. Miyata, Y. Kakizawa, N. Nishiyama, Y. Yamasaki, T. Watanabe, M. Kohara, K. Kataoka, Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelles with disulfide crosslinked cores to the liver. J. Control. Release 109 (1-3) 15-23 (2005) (DOI: 10.1016/j.jconrel.2005.09.043)
  82. N. Nishiyama, A. Iriyama, W. -D. Jang, K. Miyata, K. Itaka, Y. Inoue, H. Takahashi, Y. Yanagi, Y. Tamaki, H. Koyama, K. Kataoka, Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer. Nat. Mater. 4 (12) 934-941 (2005) (DOI: 10.1038/nmat1524)
  83. S. Fukushima, K. Miyata, N. Nishiyama, N. Kanayama, Y. Yamasaki, K. Kataoka, PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery. J. Am. Chem. Soc. 127 (9) 2810-2811 (2005) (DOI: 10.1021/ja0440506)
  84. D. Wakebayashi, N. Nishiyama, K. Itaka, K. Miyata, Y. Yamasaki, A. Harada, H. Koyama, Y. Nagasaki, K. Kataoka, Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficacy. Biomacromolecules 5 (6) 2128-2136 (2004) (DOI: 10.1021/bm040009j)
  85. Y. Kakizawa, K. Miyata, S. Furukawa, K. Kataoka, Size-controlled formation of a calcium phosphate-based organic-inorganic hybrid vector for gene delivery using poly(ethylene glycol)-block-poly(aspartic acid). Adv. Mater. 16 (8) 699-702 (2004) (DOI: 10.1002/adma.200305782)
  86. K. Miyata, Y. Kakizawa, N. Nishiyama, A. Harada, Y. Yamasaki, H. Koyama, K. Kataoka, Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. J. Am. Chem. Soc. 126 (8) 2355-2361 (2004) (DOI: 10.1021/ja0379666)
Miyata laboratory
The University of Tokyo, Department of Materials Engineering, Bld.#4, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656